1-[5-(6-Benzyloxy-7-methoxy-1-methylene-3,4-dihydro-1H-isoquinoline-2-carbonyl)-pyridin-3-yl]-ethanone

Base Information

Chemical Name:1-[5-(6-Benzyloxy-7-methoxy-1-methylene-3,4-dihydro-1H-isoquinoline-2-carbonyl)-pyridin-3-yl]-ethanone
CAS No.:132148-47-1
Molecular Formula:C₂₆H₂₄N₂O₄
Molecular Weight:428.488
Hs Code.:

Synonyms:1-[5-(6-Benzyloxy-7-methoxy-1-methylene-3,4-dihydro-1H-isoquinoline-2-carbonyl)-pyridin-3-yl]-ethanone

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Chemical Property of 1-[5-(6-Benzyloxy-7-methoxy-1-methylene-3,4-dihydro-1H-isoquinoline-2-carbonyl)-pyridin-3-yl]-ethanone

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Technology Process of 1-[5-(6-Benzyloxy-7-methoxy-1-methylene-3,4-dihydro-1H-isoquinoline-2-carbonyl)-pyridin-3-yl]-ethanone

There total 3 articles about 1-[5-(6-Benzyloxy-7-methoxy-1-methylene-3,4-dihydro-1H-isoquinoline-2-carbonyl)-pyridin-3-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

: 6857-58-5
6-benzyloxy-7-methoxy-1-methyl-3,4-dihydroisoquinoline

: 54698-27-0
3-acetyl nicotinyl chloride

: 132148-47-1
1-[5-(6-Benzyloxy-7-methoxy-1-methylene-3,4-dihydro-1H-isoquinoline-2-carbonyl)-pyridin-3-yl]-ethanone

Guidance literature:: With triethylamine; In benzene; for 1h; ice bath;
DOI:10.1016/S0040-4020(01)90087-0

Reference yield:

: 38940-61-3
methyl 5-acetylpyridine-3-carboxylate

: 132148-47-1
1-[5-(6-Benzyloxy-7-methoxy-1-methylene-3,4-dihydro-1H-isoquinoline-2-carbonyl)-pyridin-3-yl]-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) aq. 1N NaOH, 2.) oxalyl chloride / 1.) 4 h reflux, 2.) benzene, 1.5 h reflux

2: 96.6 percent / triethylamine / benzene / 1 h / ice bath

With sodium hydroxide; oxalyl dichloride; triethylamine; In benzene;
DOI:10.1016/S0040-4020(01)90087-0

Reference yield:

: 132148-44-8
3-acetyl-5-carbomethoxy-1,4-dihydropyridine

: 132148-47-1
1-[5-(6-Benzyloxy-7-methoxy-1-methylene-3,4-dihydro-1H-isoquinoline-2-carbonyl)-pyridin-3-yl]-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / DDQ / benzene / 12 h / Heating

2: 1.) aq. 1N NaOH, 2.) oxalyl chloride / 1.) 4 h reflux, 2.) benzene, 1.5 h reflux

3: 96.6 percent / triethylamine / benzene / 1 h / ice bath

With sodium hydroxide; oxalyl dichloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene;
DOI:10.1016/S0040-4020(01)90087-0