38940-61-3

Usage

Uses

Used in Pharmaceutical Industry:
5-Acetylnicotinic acid methyl ester is used as a chemical intermediate for the synthesis of new drugs and drug candidates, leveraging its potential biological activities such as anticancer and anti-inflammatory properties.
Used in Agrochemical Industry:
Although not explicitly mentioned in the provided materials, given its use as an intermediate in the synthesis of agrochemicals, 5-Acetylnicotinic acid methyl ester could be used as a precursor in the development of compounds with pesticidal or herbicidal properties, contributing to crop protection and yield enhancement.
It is crucial to handle 5-Acetylnicotinic acid methyl ester with care due to its potentially hazardous nature and associated health risks, underscoring the importance of safety measures in research and development processes.

Upstream product

• 350-03-8 methyl-3-pyridylketone 
• 29681-44-5 5-bromo-3-pyridine carboxylic acid methyl ester 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 50628-25-6 methyl-2-formyl-3-methoxypropionate sodium 
• 4591-55-3 dimethyl pyridine-3,5-dicarboxylate 
• 592543-51-6 1-(5-acetyl-1-benzhydryl-1,4-dihydro-pyridin-3-yl)-2,2,2-trichloro-ethanone 
• 1027913-81-0 1-(1-benzhydryl-1,4-dihydro-pyridin-3-yl)-ethanone 
• 754215-70-8 methyl 3-acetyl-1-benzhydryl-α-(methylsulfanyl)-5-(trichloroacetyl)-1,4-dihydropyridine-4-acetate 
• 754215-71-9 methyl 3-acetyl-1-benzhydryl-5-(methoxycarbonyl)-1,4-dihydropyridine-4-acetate 
• 592543-54-9 5-acetyl-1-benzhydryl-1,4-dihydro-pyridine-3-carboxylic acid methyl ester 
• 101025-91-6 methyl 5-methoxycarbonylacetylnicotinate 
• 132148-44-8 3-acetyl-5-carbomethoxy-1,4-dihydropyridine 

Downstream Products

• 60699-65-2 5-(2-Bromo-acetyl)-nicotinic acid methyl ester 
• 1356483-63-0 5-acetyl-N-[2-(cyclopropylamino)-4-fluorophenyl]pyridine-3-carboxamide 
• 132148-48-2 9-Acetyl-3-benzyloxy-2-methoxy-5,6-dihydro-6a,11-diaza-benzo[a]anthracen-7-one 
• 132148-49-3 11-Acetyl-3-benzyloxy-2-methoxy-5,6-dihydro-6a,9-diaza-benzo[a]anthracen-7-one 
• 132148-47-1 1-[5-(6-Benzyloxy-7-methoxy-1-methylene-3,4-dihydro-1H-isoquinoline-2-carbonyl)-pyridin-3-yl]-ethanone 
• 98664-62-1 (5-ethylpyridin-3-yl)methanol 
• 38940-64-6 5-(1'-hydroxyethyl) nicotinic acid methyl ester 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS RELATED TO MOLECULAR CONJUGATION

The invention relates to activated Michael acceptor (AMA) compounds that can undergo conjugation with biomolecules containing Michael donor moieties, thereby providing plasma-stable antibody-drug conjugates (ADCs). Pharmaceutical compositions of the ADCs are disclosed as well. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.

FUSED HETEROCYCLIC BENZODIAZEPINE DERIVATIVES AND USES THEREOF

The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

NOVEL BENZODIAZEPINE DERIVATIVES AND USES THEREOF

The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

Palladium-catalyzed regiocontrolled internal heteroarylation of electron-rich olefins with heteroaryl halides

A highly efficient palladium-catalyzed Heck coupling reaction of heteroaryl halides with electron-rich vinyl ether and hydroxyalkyl vinyl ethers is described. It was found that the choice of solvent, ligand, and reaction temperature had a fundamental influence on the regioselectivity and reactivity of the reaction, and the combination of Pd(OAc)2 and DPPF in ethylene glycol led to the most effective catalytic system. Under these conditions, a variety of heteroaryl halides reacted very quickly with electron-rich olefins to afford exclusively the branched products in good to excellent yields without employing triflates, halide scavengers, or ionic liquids.

Total synthesis of the naphthyridine alkaloid jasminine

The synthesis of (±)-jasminine (1), a member of a small group of naphthyridine alkaloids, has been achieved. The synthetic route takes advantage of the reactivity of dihydropyridine intermediates for the preparation of trisubstituted pyridine 4, which giv

A synthetic entry to 3,5-disubstituted pyridines

A straightforward entry to 3,5-disubstituted pyridines from 3-substituted pyridines, based on the acylation of N-alkyl-1,4-dihydropyridine derivatives followed by a tandem N-dealkylation-oxidation sequence is reported.

Total Syntheses and Antimicrobial Activities of Pyridine Alkaloids from Rubiaceae

Pyridine alkaloids from Rubiaceae were prepared by palladium-catalyzed cross-coupling reactions of methyl 5-bromonicotinate (6) with various organometallic reagents.Baker's yeast reduction of the ketone 8 gave the levorotatory alcohol (S)-1.On this basis, the naturally occuring alcohol (+)-1 was assigned to be (R)-configurated.The alkaloids 1 and 4 show weak antimicrobial activities. - Keywords: Pyridine alkaloids; Palladium catalyst; Baker's yeast; Antimicrobial activity

A novel one-pot synthesis of substituted 1,4-dihydropyridines and its application to total synthesis of the alkaloid isoalamarine from Alangium lamarckii Thw

A novel method for one pot synthesis of unsymmetrical 3,5-disubstituted and 3,4,5,-trisubstituted 1,4-dihydropyridines has been developed. The first total synthesis of the alkaloid isoalamarine (1), involving 3-acetyl-5-carbomethoxy pyridine has been acco

13C NMR SPECTRAL AND STEREOCHEMICAL ANALYSIS OF PIPERIDINE DERIVED α-AMINONITRILES

Carbon-13 NMR spectra of several α-aminonitriles are reported, along with their preparation via the modified Polonovski reaction or the reductive cyanation of Fry.The substituent effects for the cyano group in the different nitrogen heterocycles were dete