Ribavirin amidine

Base Information

• Chemical Name: Ribavirin amidine
• CAS No.: 40372-00-7
• Molecular Formula: C8H14ClN5O4
• Molecular Weight: 279.683
• Mol file: 40372-00-7.mol

Synonyms:AVS 206;Viramidine hydrochloride;Ribamidine hydrochloride;1-|A-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboximidamide Monohydrochloride;

Chemical Property of Ribavirin amidine

Chemical Property:

• Vapor Pressure: 5.01E-15mmHg at 25°C
• Melting Point: 167-172°C
• Boiling Point: 595.5°C at 760 mmHg
• Flash Point: 313.9°C
• PSA: 150.50000
• LogP: -1.22430
• Storage Temp.: -20?C Freezer
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

Viramidine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Liver-targeting antiviral nucleoside analog; 3-carboxamidine prodrug of Ribavirin.

Technology Process of Ribavirin amidine

There total 6 articles about Ribavirin amidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-cyano-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1,2,4-triazole (40371-99-1) → ribamidine hydrochloride (40372-00-7)

Guidance literature:

With ammonia; ammonium chloride; at 85 ℃; for 18h; Product distribution / selectivity;

Reference yield: 93.0%

methanolic sodium methoxide + methyl 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboximidate (120362-25-6) + 3-cyano-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1,2,4-triazole (40371-99-1) → ribamidine hydrochloride (40372-00-7)

Guidance literature:

With ammonium chloride; ammonia; In methanol;

Reference yield: 93.0%

methyl 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboximidate (120362-25-6) → ribamidine hydrochloride (40372-00-7)

Guidance literature:

With ammonia; ammonium chloride; In methanol; Ambient temperature;

DOI:10.1021/jm00127a008

upstream raw materials:

methyl 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboximidate

2',3',5'-Tri-O-acetyl-1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide

ribavirin

3-cyano-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1,2,4-triazole

Downstream raw materials:

ribavirin

Refernces

• 1、 -. "Specificity in treatment of diseases". . . Retrieved 2008/06/13.
• 2、 -. "Synthesis and anti-leukemic activity of alkyl-1-(β-D-ribofuranosyl)[1,2,4]triazole-3-carboximidates". . . Retrieved 2008/06/13.