2,2-Dimethyl-propionic acid 2-{(2R,6R)-4-hydroxy-4-hydroxymethyl-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-ethyl ester

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Chemical Name:2,2-Dimethyl-propionic acid 2-{(2R,6R)-4-hydroxy-4-hydroxymethyl-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-ethyl ester
CAS No.:224578-32-9
Molecular Formula:C₂₅H₃₅NO₈
Molecular Weight:477.555
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid 2-{(2R,6R)-4-hydroxy-4-hydroxymethyl-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-ethyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid 2-{(2R,6R)-4-hydroxy-4-hydroxymethyl-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-ethyl ester

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Technology Process of 2,2-Dimethyl-propionic acid 2-{(2R,6R)-4-hydroxy-4-hydroxymethyl-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-ethyl ester

There total 12 articles about 2,2-Dimethyl-propionic acid 2-{(2R,6R)-4-hydroxy-4-hydroxymethyl-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 224578-19-2
2,2-Dimethyl-propionic acid 2-{(2S,6R)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester

: 224578-32-9
2,2-Dimethyl-propionic acid 2-{(2R,6R)-4-hydroxy-4-hydroxymethyl-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-ethyl ester

Guidance literature:: With osmium(VIII) oxide; sodium hydrogencarbonate; potassium carbonate; potassium hexacyanoferrate(III); In water; tert-butyl alcohol;
DOI:10.1016/S0040-4039(99)00209-9

Reference yield:

: 88920-24-5
p-methoxybenzyloxy acetic acid

: 224578-32-9
2,2-Dimethyl-propionic acid 2-{(2R,6R)-4-hydroxy-4-hydroxymethyl-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-ethyl ester

Guidance literature:: Multi-step reaction with 11 steps

2: DAST

3: 81 percent / BrCCl₃, DBU

4: 90 percent / DIBAL / CH₂Cl₂ / 0.17 h / -78 °C

5: 1.) (R,R)-1,2-diamino-1,2-diphenylethane bis-sulfonamide, BBr₃ / 1.) CH₂Cl₂, 12 h, 2.) CH₂Cl₂, -78 deg C

6: PPTs / CH₂Cl₂

7: TBAF / tetrahydrofuran

8: Et₃N / CH₂Cl₂

9: TsOH / methanol

10: NaH / toluene

11: 99 percent / OsO₄, K₃Fe(CN)6, K₂CO₃, NaHCO₃ / 2-methyl-propan-2-ol; H₂O

With osmium(VIII) oxide; Bromotrichloromethane; (R,R)-1,2-diamino-1,2-diphenylethane bis-sulfonamide; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; boron tribromide; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 4,4'-diaminostilbene-2,2'-disulfonic acid; potassium hexacyanoferrate(III); In tetrahydrofuran; methanol; dichloromethane; water; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4039(99)00209-9

Reference yield:

: 224578-16-9
2-(4-Methoxy-benzyloxymethyl)-oxazole-4-carbaldehyde

: 224578-32-9
2,2-Dimethyl-propionic acid 2-{(2R,6R)-4-hydroxy-4-hydroxymethyl-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-2-yl}-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) (R,R)-1,2-diamino-1,2-diphenylethane bis-sulfonamide, BBr₃ / 1.) CH₂Cl₂, 12 h, 2.) CH₂Cl₂, -78 deg C

2: PPTs / CH₂Cl₂

3: TBAF / tetrahydrofuran

4: Et₃N / CH₂Cl₂

5: TsOH / methanol

6: NaH / toluene

7: 99 percent / OsO₄, K₃Fe(CN)6, K₂CO₃, NaHCO₃ / 2-methyl-propan-2-ol; H₂O

With osmium(VIII) oxide; (R,R)-1,2-diamino-1,2-diphenylethane bis-sulfonamide; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; boron tribromide; sodium hydride; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; potassium hexacyanoferrate(III); In tetrahydrofuran; methanol; dichloromethane; water; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4039(99)00209-9