1,14-bis(2,3-dimethoxybenzoyl)-1,5,10,14-tetraazatetradecane

Base Information

• Chemical Name: 1,14-bis(2,3-dimethoxybenzoyl)-1,5,10,14-tetraazatetradecane
• CAS No.: 146980-28-1
• Molecular Formula: C₂₈H₄₂N₄O₆
• Molecular Weight: 530.665
• Mol file: 146980-28-1.mol

Synonyms:1,14-bis(2,3-dimethoxybenzoyl)-1,5,10,14-tetraazatetradecane

Chemical Property of 1,14-bis(2,3-dimethoxybenzoyl)-1,5,10,14-tetraazatetradecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,14-bis(2,3-dimethoxybenzoyl)-1,5,10,14-tetraazatetradecane

There total 2 articles about 1,14-bis(2,3-dimethoxybenzoyl)-1,5,10,14-tetraazatetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Spermine (71-44-3) + 3-[(2,3-dimethoxyphenyl)carbonyl]thiazolidine-2-thione (144344-71-8) → 1,14-bis(2,3-dimethoxybenzoyl)-1,5,10,14-tetraazatetradecane (146980-28-1)

Guidance literature:

In dichloromethane; for 3h;

DOI:10.1021/jm00056a011

Reference yield:

Spermine (71-44-3) + 2,3-dimethoxybenzoic acid (1521-38-6) → 1,14-bis(2,3-dimethoxybenzoyl)-1,5,10,14-tetraazatetradecane (146980-28-1)

Guidance literature:

With 1,1'-carbonyldiimidazole;

DOI:10.1039/c9sc01068h

Reference yield:

1,14-bis(2,3-dimethoxybenzoyl)-1,5,10,14-tetraazatetradecane (146980-28-1) → 1-Hydroxy-6-oxo-1,6-dihydro-pyridine-2-carboxylic acid [3-(2,3-dihydroxy-benzoylamino)-propyl]-(4-{(2,3-dihydroxy-benzoyl)-[3-(2,3-dihydroxy-benzoylamino)-propyl]-amino}-butyl)-amide (146980-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 1,1'-carbonyldiimidazole (CDI)

2: BBr₃ / CH₂Cl₂

With boron tribromide; 1,1'-carbonyldiimidazole; In dichloromethane;

DOI:10.1021/jm00056a011

upstream raw materials:

Spermine

3-[(2,3-dimethoxyphenyl)carbonyl]thiazolidine-2-thione

2,3-dimethoxybenzoic acid

Downstream raw materials:

C₄₀H₄₈N₆O₁₂

1-Hydroxy-6-oxo-1,6-dihydro-pyridine-2-carboxylic acid [3-(2,3-dimethoxy-benzoylamino)-propyl]-(4-{(2,3-dimethoxy-benzoyl)-[3-(2,3-dimethoxy-benzoylamino)-propyl]-amino}-butyl)-amide

1-Hydroxy-6-oxo-1,6-dihydro-pyridine-2-carboxylic acid [3-(2,3-dihydroxy-benzoylamino)-propyl]-(4-{(2,3-dihydroxy-benzoyl)-[3-(2,3-dihydroxy-benzoylamino)-propyl]-amino}-butyl)-amide

1,14-bis(2,3-dihydroxybenzoyl)-5,10-bis(1-hydroxy-2-pyridon-6-oyl)-1,5,10,14-tetraazatetradecane