(3aR,8aS)-3-Benzoyl-2-(2,4-dimethoxy-phenyl)-2,3,3a,8-tetrahydro-indeno[1,2-d]oxazole-8a-carboxylic acid

Base Information

• Chemical Name: (3aR,8aS)-3-Benzoyl-2-(2,4-dimethoxy-phenyl)-2,3,3a,8-tetrahydro-indeno[1,2-d]oxazole-8a-carboxylic acid
• CAS No.: 343868-88-2
• Molecular Formula: C₂₆H₂₃NO₆
• Molecular Weight: 445.472
• Mol file: 343868-88-2.mol

Synonyms:(3aR,8aS)-3-Benzoyl-2-(2,4-dimethoxy-phenyl)-2,3,3a,8-tetrahydro-indeno[1,2-d]oxazole-8a-carboxylic acid

Chemical Property of (3aR,8aS)-3-Benzoyl-2-(2,4-dimethoxy-phenyl)-2,3,3a,8-tetrahydro-indeno[1,2-d]oxazole-8a-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aR,8aS)-3-Benzoyl-2-(2,4-dimethoxy-phenyl)-2,3,3a,8-tetrahydro-indeno[1,2-d]oxazole-8a-carboxylic acid

There total 1 articles about (3aR,8aS)-3-Benzoyl-2-(2,4-dimethoxy-phenyl)-2,3,3a,8-tetrahydro-indeno[1,2-d]oxazole-8a-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dimethoxybenzaldehyde dimethylacetal (91352-76-0) + (1R,2S)-ethyl 1-benzoylamino-2-hydroxyindan-2-carboxylate (343868-87-1) → (3aR,8aS)-3-Benzoyl-2-(2,4-dimethoxy-phenyl)-2,3,3a,8-tetrahydro-indeno[1,2-d]oxazole-8a-carboxylic acid (343868-88-2)

Guidance literature:

With pyridinium p-toluenesulfonate; In toluene; for 2h; Heating;

DOI:10.1021/jm001103v

Reference yield:

7-(triethylsilyl)baccatin III (115437-21-3) + (3aR,8aS)-3-Benzoyl-2-(2,4-dimethoxy-phenyl)-2,3,3a,8-tetrahydro-indeno[1,2-d]oxazole-8a-carboxylic acid (343868-88-2) → C63H73NO16Si

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In toluene; at 20 - 70 ℃;

DOI:10.1021/jm001103v

Reference yield:

(3aR,8aS)-3-Benzoyl-2-(2,4-dimethoxy-phenyl)-2,3,3a,8-tetrahydro-indeno[1,2-d]oxazole-8a-carboxylic acid (343868-88-2) → C48H51NO14

Guidance literature:

Multi-step reaction with 2 steps

1: DCC; DMAP / toluene / 20 - 70 °C

2: 0.1 M methanolic HCl / 1.5 h / 20 °C

With hydrogenchloride; dmap; dicyclohexyl-carbodiimide; In toluene;

DOI:10.1021/jm001103v

upstream raw materials:

2,4-dimethoxybenzaldehyde dimethylacetal

(1R,2S)-ethyl 1-benzoylamino-2-hydroxyindan-2-carboxylate