Di-tert-butyl 4-hydroxypyrrolidine-1,3-dicarboxylate

Base Information

Chemical Name:Di-tert-butyl 4-hydroxypyrrolidine-1,3-dicarboxylate
CAS No.:797038-36-9
Molecular Formula:C₁₄H₂₅NO₅
Molecular Weight:287.356
Hs Code.:
DSSTox Substance ID:DTXSID10473660,DTXSID001169459

Synonyms:Di-tert-butyl 4-hydroxypyrrolidine-1,3-dicarboxylate;203434-46-2;DTXSID10473660;DTXSID001169459;797038-36-9;Di-tert-butyl4-hydroxypyrrolidine-1,3-dicarboxylate;1,3-Bis(1,1-dimethylethyl) 4-hydroxy-1,3-pyrrolidinedicarboxylate

Suppliers and Price of Di-tert-butyl 4-hydroxypyrrolidine-1,3-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Di-tert-butyl 4-hydroxypyrrolidine-1,3-dicarboxylate

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:287.17327290
Heavy Atom Count:20
Complexity:380

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)C1CN(CC1O)C(=O)OC(C)(C)C

Technology Process of Di-tert-butyl 4-hydroxypyrrolidine-1,3-dicarboxylate

There total 1 articles about Di-tert-butyl 4-hydroxypyrrolidine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31954-27-5
N-(tert-butoxycarbonyl)glycine methyl ester

: 797038-36-9
tert-butyl N-tert-butyloxycarbonyl-4-hydroxypyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / t-BuOK / tetrahydrofuran / 24 h / 20 °C

2: NaBH₃CN; aq.HCl / methanol / 1.33 h / 20 °C / pH 3 - 4

With hydrogenchloride; potassium tert-butylate; sodium cyanoborohydride; In tetrahydrofuran; methanol;
DOI:10.1039/b407558g

Reference yield:

: 797038-36-9
tert-butyl N-tert-butyloxycarbonyl-4-hydroxypyrrolidine-3-carboxylate

: 797038-58-5
tert-butyl N-tert-butyloxycarbonyl-(3R,4R,αS)-4-(N-benzyl-N-α-methylbenzylamino)tetrahydropyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / PPh₃; DIAD / tetrahydrofuran / 20 °C

2.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C

2.2: 46 percent / tetrahydrofuran / 3 h / -78 °C

With n-butyllithium; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;
DOI:10.1039/b407558g