BOC-GLY-OME

Base Information

• Chemical Name: BOC-GLY-OME
• CAS No.: 31954-27-5
• Molecular Formula: C8H15NO4
• Molecular Weight: 189.211
• Hs Code.: 29241990
• Mol file: 31954-27-5.mol

Synonyms:Glycine,N-carboxy-, N-tert-butyl methyl ester (6CI);(tert-Butoxycarbonylamino)aceticacid methyl ester;BOC-glycine methyl ester;MethylN-[[(1,1-dimethylethyl)oxy]carbonyl]glycinate;N-(Carbo-tert-butyloxy)glycinemethyl ester;N-(tert-Butoxycarbonyl)glycine methyl ester;N-Boc-glycine methylester;

Chemical Property of BOC-GLY-OME

Chemical Property:

• Vapor Pressure: 0.00845mmHg at 25°C
• Refractive Index: n20/D 1.437(lit.)
• Boiling Point: 266.8 °C at 760 mmHg
• PKA: 11.06±0.46(Predicted)
• Flash Point: 115.2 °C
• PSA: 64.63000
• Density: 1.072 g/cm³
• LogP: 1.07500
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Chloroform, Ethyl Acetate

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(tert-Butoxycarbonyl)glycine Methyl Ester >98.0%(N) ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Boc-glycine methyl ester is a amino acid glycine (G615990) derivative, used widely in various synthetic preparations of pharmaceutical goods and antioxidants. N-[(1,1-Dime thylethoxy)carbonyl]glycine Methyl Ester can be used in the preparation of Pregabalin (P704800), a GABA analogue used as an anticonvulsant. It is used as a pharmaceutical, chemical, paint and dye intermediate.

Technology Process of BOC-GLY-OME

There total 27 articles about BOC-GLY-OME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → N-(tert-butoxycarbonyl)glycine methyl ester (31954-27-5)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; Cooling with ice;

DOI:10.3762/bjoc.12.285

Reference yield: 99.0%

methanol (67-56-1) + BOC-glycine (4530-20-5) → N-(tert-butoxycarbonyl)glycine methyl ester (31954-27-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/chem.201604247

Reference yield: 98.0%

allyl methyl malonate (57218-61-8) + tert-butyl alcohol (75-65-0) → N-(tert-butoxycarbonyl)glycine methyl ester (31954-27-5)

Guidance literature:

With sodium azide; diphenyl phosphoryl azide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 80 ℃; for 20h;

upstream raw materials:

N-(tert-butyloxycarbonyl) azide

glycine ethyl ester hydrochloride

di-tert-butyl dicarbonate

methoxycarbonylmethylamine

Downstream raw materials:

2-bromo-2-(N-tert-butoxycarbonylamino)acetic acid methyl ester

(tert-butoxycarbonyl)glycine hydrazide

tert-butyl (2-hydroxy-2-methylpropyl)carbamate

N-tert-butoxycarbonyl-N-[2-(dimethylphenylsilanyl)but-2(Z)-enyl]glycine methyl ester

Refernces

• 1、 Dong, Jiaqiang,Huang, Jingjie,Zhou, Ji,Tan, Ye,Jin, Jing,Tan, Xi,Wang, Bei,Yu, Tao,Wu, Chengde,Chen, Shuhui,Wang, Tie-Lin. "Discovery of 3-Quinazolin-4(3 H)-on-3-yl-2, N-dimethylpropanamides as Orally Active and Selective PI3Kα Inhibitors". supporting information. p. 1463 - 1469. Retrieved 2020/08/14.
• 2、 -. "COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES". Page/Page column 111. . Retrieved 2019/07/19.