tert-butyl [2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)-phenyl]propyl}piperidin-4-yl)ethyl]carbamate

Base Information

Chemical Name:tert-butyl [2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)-phenyl]propyl}piperidin-4-yl)ethyl]carbamate
CAS No.:835876-99-8
Molecular Formula:C₂₈H₃₈F₂N₂O₄S
Molecular Weight:536.684
Hs Code.:

Synonyms:tert-butyl [2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)-phenyl]propyl}piperidin-4-yl)ethyl]carbamate

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Chemical Property of tert-butyl [2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)-phenyl]propyl}piperidin-4-yl)ethyl]carbamate

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Technology Process of tert-butyl [2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)-phenyl]propyl}piperidin-4-yl)ethyl]carbamate

There total 1 articles about tert-butyl [2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)-phenyl]propyl}piperidin-4-yl)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 718610-25-4
(R) 3-(1-methanesulphonylpiperidin-4-yl)-3-[3,5-difluorophenyl]propionaldehyde

: 712264-43-2
tert-butyl 4-piperidin-4-ylbutanoate

: 835876-99-8
tert-butyl [2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)-phenyl]propyl}piperidin-4-yl)ethyl]carbamate

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane;

Reference yield:

: 835876-99-8
tert-butyl [2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)-phenyl]propyl}piperidin-4-yl)ethyl]carbamate

: 835877-00-4
[2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-piperidin-4-yl)ethyl]amine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 1.5h;

Reference yield:

: 835876-99-8
tert-butyl [2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)-phenyl]propyl}piperidin-4-yl)ethyl]carbamate

: C₂₉H₃₅F₂N₃O₄S₂

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 1.5 h

2: pyridine / dichloromethane / 2 h

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 760.05 Torr

With pyridine; hydrogenchloride; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;