[2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-piperidin-4-yl)ethyl]amine

Base Information

Chemical Name:[2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-piperidin-4-yl)ethyl]amine
CAS No.:835877-00-4
Molecular Formula:C₂₃H₃₀F₂N₂O₂S
Molecular Weight:436.566
Hs Code.:

Synonyms:[2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-piperidin-4-yl)ethyl]amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-piperidin-4-yl)ethyl]amine

Chemical Property:

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Technology Process of [2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-piperidin-4-yl)ethyl]amine

There total 1 articles about [2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-piperidin-4-yl)ethyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 835876-99-8
tert-butyl [2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)-phenyl]propyl}piperidin-4-yl)ethyl]carbamate

: 835877-00-4
[2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-piperidin-4-yl)ethyl]amine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 1.5h;

Reference yield:

: 835877-00-4
[2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-piperidin-4-yl)ethyl]amine

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: C₂₉H₃₃F₂N₃O₆S₂

Guidance literature:: With pyridine; In dichloromethane; for 2h;

Reference yield:

: 835877-00-4
[2-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-piperidin-4-yl)ethyl]amine

: C₂₉H₃₅F₂N₃O₄S₂

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 2 h

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 760.05 Torr

With pyridine; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;