tert-Butyl 6-(tert-butyldiphenylsilyloxy)-3-(trifluoromethyl)-indazole-1-carboxylate

Base Information

Chemical Name:tert-Butyl 6-(tert-butyldiphenylsilyloxy)-3-(trifluoromethyl)-indazole-1-carboxylate
CAS No.:1221178-81-9
Molecular Formula:C₂₉H₃₁F₃N₂O₃Si
Molecular Weight:540.657
Hs Code.:

Synonyms:tert-Butyl 6-(tert-butyldiphenylsilyloxy)-3-(trifluoromethyl)-indazole-1-carboxylate

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Chemical Property of tert-Butyl 6-(tert-butyldiphenylsilyloxy)-3-(trifluoromethyl)-indazole-1-carboxylate

Chemical Property:

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Technology Process of tert-Butyl 6-(tert-butyldiphenylsilyloxy)-3-(trifluoromethyl)-indazole-1-carboxylate

There total 8 articles about tert-Butyl 6-(tert-butyldiphenylsilyloxy)-3-(trifluoromethyl)-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1221178-80-8
6-((tert-butyldiphenylsilyl)oxy)-3-(trifluoromethyl)-1H-indazole

: 1221178-81-9
tert-Butyl 6-(tert-butyldiphenylsilyloxy)-3-(trifluoromethyl)-indazole-1-carboxylate

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 17484-36-5
4-Methyl-3-nitroanisole

: 1221178-81-9
tert-Butyl 6-(tert-butyldiphenylsilyloxy)-3-(trifluoromethyl)-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane; water / 3 h / Inert atmosphere; Reflux

2.1: copper(l) iodide / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

3.1: hydrogen / 5%-palladium/activated carbon / water; methanol / 20 °C

4.1: potassium acetate / chlorobenzene / 0.08 h / 80 °C

4.2: 67 h / 20 - 80 °C

5.1: hydrogen bromide / 110 °C

5.2: 0 °C / pH ~ 7

6.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

7.1: triethylamine / dmap / tetrahydrofuran / 20 °C

With 1H-imidazole; N-Bromosuccinimide; hydrogen bromide; hydrogen; potassium acetate; triethylamine; dmap; copper(l) iodide; 5%-palladium/activated carbon; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; water; N,N-dimethyl-formamide; chlorobenzene;

Reference yield:

: 57559-52-1
4-methoxy-2-nitrobenzyl bromide

: 1221178-81-9
tert-Butyl 6-(tert-butyldiphenylsilyloxy)-3-(trifluoromethyl)-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(l) iodide / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

2.1: hydrogen / 5%-palladium/activated carbon / water; methanol / 20 °C

3.1: potassium acetate / chlorobenzene / 0.08 h / 80 °C

3.2: 67 h / 20 - 80 °C

4.1: hydrogen bromide / 110 °C

4.2: 0 °C / pH ~ 7

5.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

6.1: triethylamine / dmap / tetrahydrofuran / 20 °C

With 1H-imidazole; hydrogen bromide; hydrogen; potassium acetate; triethylamine; dmap; copper(l) iodide; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; chlorobenzene;