(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(N-(tert-butoxycarbonyl)(methyl)sulfonamido)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-trifluoromethyl-1-carboxylate

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Chemical Name:(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(N-(tert-butoxycarbonyl)(methyl)sulfonamido)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-trifluoromethyl-1-carboxylate
CAS No.:1221178-83-1
Molecular Formula:C₄₀H₅₉F₃N₄O₁₀SSi
Molecular Weight:873.076
Hs Code.:

(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(N-(tert-butoxycarbonyl)(methyl)sulfonamido)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-trifluoromethyl-1-carboxylate

Synonyms:(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(N-(tert-butoxycarbonyl)(methyl)sulfonamido)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-trifluoromethyl-1-carboxylate

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Chemical Property of (R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(N-(tert-butoxycarbonyl)(methyl)sulfonamido)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-trifluoromethyl-1-carboxylate

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Technology Process of (R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(N-(tert-butoxycarbonyl)(methyl)sulfonamido)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-trifluoromethyl-1-carboxylate

There total 13 articles about (R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(N-(tert-butoxycarbonyl)(methyl)sulfonamido)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-trifluoromethyl-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1221178-82-0
tert-butyl 6-hydroxy-3-(trifluoromethyl)-1H-indazole-1-carboxylate

: 1221179-01-6
tert-butyl N-(3-((1R)-2-(tert-butoxycarbonyl(2-hydroxyethyl)amino)-1-triethylsilyloxyethyl)phenyl)-N-methylsulfonylcarbamate

: 1221178-83-1
(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(N-(tert-butoxycarbonyl)(methyl)sulfonamido)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-trifluoromethyl-1-carboxylate

Guidance literature:: With diamide; triphenylphosphine; In toluene; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b00638

Reference yield:

: 1221178-77-3
5-methoxy-2-(2,2,2-trifluoroethyl)benzenamine

: 1221178-83-1
(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(N-(tert-butoxycarbonyl)(methyl)sulfonamido)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-trifluoromethyl-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium acetate / chlorobenzene / 0.33 h / 80 °C

2: isopentyl nitrite / chlorobenzene / 19 h / 80 °C

3: hydrogen bromide / water / 110 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

5: triethylamine; dmap / tetrahydrofuran / 20 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C

7: triphenylphosphine; diamide / toluene / 20 °C

With 1H-imidazole; dmap; diamide; tetrabutyl ammonium fluoride; hydrogen bromide; potassium acetate; triethylamine; triphenylphosphine; isopentyl nitrite; In tetrahydrofuran; water; N,N-dimethyl-formamide; chlorobenzene; toluene; 7: |Mitsunobu Displacement;
DOI:10.1021/acs.jmedchem.5b00638

Reference yield:

: N-(5-methoxy-2-(2,2,2-trifluoroethyl)phenyl)acetamide

: 1221178-83-1
(R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(N-(tert-butoxycarbonyl)(methyl)sulfonamido)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-trifluoromethyl-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: isopentyl nitrite / chlorobenzene / 19 h / 80 °C

2: hydrogen bromide / water / 110 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

4: triethylamine; dmap / tetrahydrofuran / 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C

6: triphenylphosphine; diamide / toluene / 20 °C

With 1H-imidazole; dmap; diamide; tetrabutyl ammonium fluoride; hydrogen bromide; triethylamine; triphenylphosphine; isopentyl nitrite; In tetrahydrofuran; water; N,N-dimethyl-formamide; chlorobenzene; toluene; 6: |Mitsunobu Displacement;
DOI:10.1021/acs.jmedchem.5b00638