2-(4-chlorophenylamino)-5-methyl-3-aminopyrimido[5,4-c]quinolin-4(3H)-one

Base Information

Chemical Name:2-(4-chlorophenylamino)-5-methyl-3-aminopyrimido[5,4-c]quinolin-4(3H)-one
CAS No.:1356399-75-1
Molecular Formula:C₁₈H₁₄ClN₅O
Molecular Weight:351.795
Hs Code.:

Synonyms:2-(4-chlorophenylamino)-5-methyl-3-aminopyrimido[5,4-c]quinolin-4(3H)-one

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Chemical Property of 2-(4-chlorophenylamino)-5-methyl-3-aminopyrimido[5,4-c]quinolin-4(3H)-one

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Technology Process of 2-(4-chlorophenylamino)-5-methyl-3-aminopyrimido[5,4-c]quinolin-4(3H)-one

There total 4 articles about 2-(4-chlorophenylamino)-5-methyl-3-aminopyrimido[5,4-c]quinolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: C₂₀H₁₆ClN₃O₂

: 1356399-75-1
2-(4-chlorophenylamino)-5-methyl-3-aminopyrimido[5,4-c]quinolin-4(3H)-one

Guidance literature:: C₂₀H₁₆ClN₃O₂; With hydrazine hydrate; In dichloromethane; at 20 ℃;

With sodium ethanolate; In ethanol; at 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2011.10.044

Reference yield:

: 163455-37-6
4-amino-2-methylquinoline-3-carboxylic acid ethyl ester

: 1356399-75-1
2-(4-chlorophenylamino)-5-methyl-3-aminopyrimido[5,4-c]quinolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hexachloroethane; triethylamine / dichloromethane / 24 h / 20 °C

2.1: dichloromethane / 12 h / 45 °C / Inert atmosphere

3.1: hydrazine hydrate / dichloromethane / 20 °C

3.2: 12 h / 20 °C

With hexachloroethane; hydrazine hydrate; triethylamine; In dichloromethane; 2.1: Aza-Wittig reaction;
DOI:10.1016/j.ejmech.2011.10.044

Reference yield:

: 1260093-46-6
C₃₁H₂₇N₂O₂P

: 1356399-75-1
2-(4-chlorophenylamino)-5-methyl-3-aminopyrimido[5,4-c]quinolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 12 h / 45 °C / Inert atmosphere

2.1: hydrazine hydrate / dichloromethane / 20 °C

2.2: 12 h / 20 °C

With hydrazine hydrate; In dichloromethane; 1.1: Aza-Wittig reaction;
DOI:10.1016/j.ejmech.2011.10.044