Ethyl 4-amino-2-methylquinoline-3-carboxylate

Base Information

• Chemical Name: Ethyl 4-amino-2-methylquinoline-3-carboxylate
• CAS No.: 163455-37-6
• Molecular Formula: C13H14N2O2
• Molecular Weight: 230.266
• Hs Code.: 2933499090
• Mol file: 163455-37-6.mol

Synonyms:Ethyl 4-amino-2-methylquinoline-3-carboxylate;4-Amino-2-methyl-quinoline-3-carboxylic acid ethyl ester;4-amino-2-methyl-3-quinolinecarboxylic acid ethyl ester

Chemical Property of Ethyl 4-amino-2-methylquinoline-3-carboxylate

Chemical Property:

• PSA: 65.21000
• LogP: 2.88330

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 4-amino-2-methylquinoline-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-amino-2-methylquinoline-3-carboxylate

There total 5 articles about Ethyl 4-amino-2-methylquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl 3-(2-nitrophenyl)-5-methylisoxazole-4-carboxylate (91956-03-5) → 4-amino-2-methylquinoline-3-carboxylic acid ethyl ester (163455-37-6)

Guidance literature:

With hydrogen; nickel; In ethanol;

Reference yield: 85.0%

ethyl acetoacetate (141-97-9) + anthranilic acid nitrile (1885-29-6) → 4-amino-2-methylquinoline-3-carboxylic acid ethyl ester (163455-37-6)

Guidance literature:

With sodium salt of sulfated chitosan; In ethanol; Reflux;

DOI:10.1016/j.tetlet.2013.07.165

Reference yield: 63.0%

ethyl 3-(2-nitrophenyl)-5-methylisoxazole-4-carboxylate (91956-03-5) → acide amino-4 methyl-2 quinoleinecarboxylique-3 (75353-49-0) + 4-amino-2-methylquinoline-3-carboxylic acid ethyl ester (163455-37-6)

Guidance literature:

With iron; acetic acid; at 80 - 120 ℃; Reagent/catalyst;

DOI:10.1002/ejoc.201403065

upstream raw materials:

ethyl 3-(2-nitrophenyl)-5-methylisoxazole-4-carboxylate

ethyl acetoacetate

anthranilic acid nitrile

N-hydroxy-2-nitrobenzimidoyl chloride

Downstream raw materials:

10-methyl-3-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin[5,4-c]quinolin-11(3H)-one

2-(phenylamino)-5-methyl-3-aminopyrimido[5,4-c]quinolin-4(3H)-one

2-(4-chlorophenylamino)-5-methyl-3-aminopyrimido[5,4-c]quinolin-4(3H)-one

2-(tert-butylamino)-3-phenyl-5-methyl-3H-pyrimido[5,4-c]quinolin-4-one

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