Technology Process of {3-[bis(4-methoxybenzyl)amino]-4-chlorophenyl}boronic acid
There total 4 articles about {3-[bis(4-methoxybenzyl)amino]-4-chlorophenyl}boronic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-bromo-2-chloro-N,N-bis(4-methoxybenzyl)aniline;
With
n-butyllithium;
In
tetrahydrofuran; diethyl ether; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
With
Triisopropyl borate;
In
tetrahydrofuran; diethyl ether; hexane;
at -78 - 20 ℃;
for 3.25h;
With
water;
In
tetrahydrofuran; diethyl ether; hexane;
Cooling with ice;
- Guidance literature:
-
5-bromo-2-chloro-N,N-bis(4-methoxybenzyl)aniline;
With
n-butyllithium;
In
tetrahydrofuran; diethyl ether; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
Triisopropyl borate;
In
tetrahydrofuran; diethyl ether; hexane;
at -78 - 20 ℃;
for 3.25h;
Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c02154
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 2 h / 0 - 20 °C
2.1: n-butyllithium / hexane; diethyl ether; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: 3.25 h / -78 - 20 °C
2.3: Cooling with ice
With
n-butyllithium; sodium hydride;
In
tetrahydrofuran; diethyl ether; hexane; mineral oil;
