Technology Process of benzyl (3-{3-[bis(4-methoxybenzyl)amino]-4-chlorophenyl}oxetan-3-yl)acetate
There total 5 articles about benzyl (3-{3-[bis(4-methoxybenzyl)amino]-4-chlorophenyl}oxetan-3-yl)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
chloro(1,5-cyclooctadiene)rhodium(I) dimer;
In
1,4-dioxane; water;
at 20 ℃;
for 4h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 2 h / 0 - 20 °C
2.1: n-butyllithium / hexane; diethyl ether; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: 3.25 h / -78 - 20 °C
2.3: Cooling with ice
3.1: potassium hydroxide / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 1,4-dioxane; water / 4 h / 20 °C / Inert atmosphere
With
n-butyllithium; sodium hydride; potassium hydroxide;
chloro(1,5-cyclooctadiene)rhodium(I) dimer;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; water; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dichloromethane / 0 - 20 °C / Inert atmosphere
2: potassium hydroxide / chloro(1,5-cyclooctadiene)rhodium(I) dimer / 1,4-dioxane; water / 4 h / 20 °C / Inert atmosphere
With
potassium hydroxide;
chloro(1,5-cyclooctadiene)rhodium(I) dimer;
In
1,4-dioxane; dichloromethane; water;
