(4S,6S)-4-(5-bromo-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Base Information

Chemical Name:(4S,6S)-4-(5-bromo-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
CAS No.:1620828-36-5
Molecular Formula:C₁₂H₁₁BrF₄N₂O
Molecular Weight:355.13
Hs Code.:

Synonyms:(4S,6S)-4-(5-bromo-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

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Chemical Property of (4S,6S)-4-(5-bromo-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Chemical Property:

Purity/Quality:

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Technology Process of (4S,6S)-4-(5-bromo-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

There total 7 articles about (4S,6S)-4-(5-bromo-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1624605-56-6
N-((4S,6S)-4-(5-bromo-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

: ammonium chloride

: 6674-22-2,83329-50-4
1,8-diazabicyclo[5.4.0]undec-7-ene

: 1620828-36-5
(4S,6S)-4-(5-bromo-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:: In ethyl acetate;

Reference yield:

: 1624605-54-4
(S)-tert-butyl 3-(5-bromo-2-fluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)butanoate

: 1620828-36-5
(4S,6S)-4-(5-bromo-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: lithium borohydride / tetrahydrofuran; ethyl acetate; methanol

2: ethyl acetate; dichloromethane

3: tetrabutyl ammonium fluoride / tetrahydrofuran; ethyl acetate

4: hydrogenchloride / 1,4-dioxane; dichloromethane; diethyl ether; hexane

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; ethyl acetate

6: ethyl acetate

With hydrogenchloride; lithium borohydride; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; hexane; dichloromethane; ethyl acetate;

Reference yield:

: (R)-N-((S)-2-(5-bromo-2-fluorophenyl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

: 1620828-36-5
(4S,6S)-4-(5-bromo-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1: ethyl acetate; dichloromethane

2: tetrabutyl ammonium fluoride / tetrahydrofuran; ethyl acetate

3: hydrogenchloride / 1,4-dioxane; dichloromethane; diethyl ether; hexane

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; ethyl acetate

5: ethyl acetate

With hydrogenchloride; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; dichloromethane; ethyl acetate;