(4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Base Information

Chemical Name:(4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
CAS No.:1432511-78-8
Molecular Formula:C₁₂H₁₃F₄N₃O
Molecular Weight:291.248
Hs Code.:

Synonyms:(4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

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Chemical Property of (4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Chemical Property:

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Technology Process of (4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

There total 14 articles about (4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432511-76-6
(4S,6S)-4-(2-fluoro-5-nitrophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

: 1432511-78-8
(4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; triethylamine; In ethanol; at 22 ℃; for 3h;
DOI:10.1021/jm400225m

Reference yield:

: 68737-65-5
(R,R)-N,N'-dimethyl-1,2-diaminocyclohexane

: 1620828-36-5
(4S,6S)-4-(5-bromo-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

: ammonium chloride

: 146-75-8,6381-77-7,6866-66-6,7317-67-1,7378-23-6,21547-69-3,58657-35-5,134-03-2
sodium L-ascorbate

: 594-09-2
trimethylphosphane

: 1432511-78-8
(4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:: In tetrahydrofuran; ethanol; water; ethyl acetate;

Reference yield:

: (3S,5S)-rac-3-(2-fluorophenyl)-3-methyl-5-trifluoromethylisoxazolidine

: 1432511-78-8
(4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1: chiralpack AD / n-heptane; ethanol

2: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / 22 - 25 °C / Inert atmosphere

3: ethanol; acetonitrile / 15 h / 85 °C / Sealed tube

4: sulfuric acid; nitric acid / 0.5 h / 0 - 22 °C

5: palladium 10% on activated carbon; hydrogen; triethylamine / ethanol / 3 h / 22 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; ammonium formate; triethylamine; In ethanol; n-heptane; acetonitrile;
DOI:10.1021/jm400225m