ethyl 2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylate

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Chemical Name:ethyl 2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylate
CAS No.:1352570-74-1
Molecular Formula:C₂₃H₂₄N₂O₇S
Molecular Weight:472.519
Hs Code.:

Synonyms:ethyl 2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylate

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Chemical Property of ethyl 2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylate

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Technology Process of ethyl 2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylate

There total 5 articles about ethyl 2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1352570-89-8
3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)benzamidine

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 1352570-74-1
ethyl 2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylate

Guidance literature:: 3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)benzamidine; diethyl 2-ethoxymethylenemalonate; With sodium ethanolate; In ethanol; at 20 - 70 ℃; Sealed tube;

With hydrogenchloride; In ethanol; water; pH=~ 2;

Reference yield:

: 3-[isopropoxy]-5-[4-(methylsulfonyl)phenoxy]benzonitrile

: 1352570-74-1
ethyl 2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium chloride; trimethylaluminum / toluene / 36 h / 110 °C

2.1: sodium ethanolate / ethanol / 20 - 70 °C / Sealed tube

2.2: pH ~ 2

With trimethylaluminum; sodium ethanolate; ammonium chloride; In ethanol; toluene;

Reference yield:

: 19179-36-3
3,5-dihydroxycyanobenzene

: 1352570-74-1
ethyl 2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 - 20 °C

1.2: 65 - 150 °C

2.1: potassium carbonate / N,N-dimethyl-formamide; mineral oil / 4 h / 65 °C

3.1: ammonium chloride; trimethylaluminum / toluene / 36 h / 110 °C

4.1: sodium ethanolate / ethanol / 20 - 70 °C / Sealed tube

4.2: pH ~ 2

With trimethylaluminum; sodium ethanolate; sodium hydride; potassium carbonate; ammonium chloride; In ethanol; N,N-dimethyl-formamide; toluene; mineral oil;