19179-36-3

Usage

Uses

Used in Chemical Synthesis:
3,5-Dihydroxybenzonitrile is used as a key intermediate in the synthesis of various organic compounds. Its presence of two hydroxyl groups and a nitrile group allows for a range of chemical reactions, making it a versatile building block for creating complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,5-dihydroxybenzonitrile is used as a starting material for the development of new drugs. Its unique structure can be modified to create compounds with specific biological activities, potentially leading to the discovery of novel therapeutic agents.
Used in the Preparation of 3-Hydroxy-5-Methoxybenzonitrile:
3,5-Dihydroxybenzonitrile is used as a reactant in the preparation of 3-hydroxy-5-methoxybenzonitrile, utilizing potassium carbonate as a reagent. This reaction is an example of the functional group transformations that can be performed using 3,5-dihydroxybenzonitrile, showcasing its utility in organic synthesis.

InChI:InChI=1/C7H5NO2/c8-4-5-1-6(9)3-7(10)2-5/h1-3,9-10H

Upstream product

• 99-10-5 3,5-Dihydroxybenzoic acid 
• 100-47-0 benzonitrile 
• 119072-55-8 tert-butylisonitrile 
• 64339-43-1 5-iodoresorcinol 
• 19179-31-8 3,5-dimethoxy-benzonitrile 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 

Downstream Products

• 361519-76-8 3-but-3-enyloxy-5-hydroxy-benzonitrile 
• 361519-77-9 3-hydroxy-5-(4-methyl-pent-3-enyloxy)-benzonitrile 
• 61227-20-1 3,5-Diacetoxy-benzonitril 
• 518058-73-6 3-(benzyloxy)-5-hydroxybenzonitrile 
• 1291074-11-7 C₅₉H₆₉NO₈ 
• 1291074-10-6 C₄₇H₄₅NO₈ 
• 1581683-85-3 ethyl 2-(3-cyano-5-hydroxyphenoxy)acetate 
• 1581683-90-0 2-(3-((4-(3-(aminomethyl)azetidin-1-yl)-6-fluoro-8-(methylamino)-9H-pyrimido[4,5-b]indol-2-yl)oxy)-5-cyanophenoxy)acetic acid trifluoroacetate 
• 1581683-88-6 2-(3-((8-((tert-butoxycarbonyl)(methyl)amino)-4-(3-(((tert-butoxycarbonyl)amino)methyl)azetidin-1-yl)-6-fluoro-9H-pyrimido[4,5-b]indol-2-yl)oxy)-5-cyanophenoxy)acetic acid 
• 1581683-87-5 ethyl 2-(3-((8-((tert-butoxycarbonyl)(methyl)amino)-4-(3-(((tert-butoxycarbonyl)amino)methyl)azetidin-1-yl)-6-fluoro-9H-pyrimido[4,5-b]indol-2-yl)oxy)-5-cyanophenoxy)acetate 
• 1581683-86-4 diethyl 2,2'-((((8-((tert-butoxycarbonyl)(methyl)amino)-6-fluoro-9H-pyrimido[4,5-b]indole-2,4-diyl)bis(oxy))bis(3-cyano-5,1-phenylene))bis(oxy))diacetate 
• 1521224-90-7 C₂₅H₂₅NO₆ 
• 1521224-85-0 C₇₄H₇₁NO₈ 
• 1391831-62-1 C₅₀H₅₅NO₁₂ 

Relevant academic research and scientific papers

Synthesis of aryl nitriles by palladium-assisted cyanation of aryl iodides using tert-butyl isocyanide as cyano source

Abstract A palladium-catalyzed synthesis of aryl nitriles by the cyanation of aryl iodides with tert-butyl isocyanide as cyano source has been developed. This novel and efficient method avoids the use of toxic cyanides. The reaction is easy-to-handle and shows good functional group compatibility.

NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

Compounds of Formula I: are HIV reverse transcriptase inhibitors, wherein R1, R2, RE, L, M and Z are defined herein. The compounds of Formula I and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines

5-PHENOXY-3H-PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS HIV REVERSE TRANSCRIPTASE INHIBITORS

Compounds of Formula (I) are HIV reverse transcriptase inhibitors, wherein R1, R2, RE, L, M and Z are defined herein. The compounds of Formula (I) and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Process for demethylating aromatic methyl ethers using 3-mercaptopropionic acid

The present application discloses a process for demethylating aromatic methyl ethers by reaction with 3-mercaptopropionic acid or salts thereof. One preferred example is the demethylation of venlafaxine forming O-desmethylvenlafaxine.

PROCESS FOR DEMETHYLATING AROMATIC METHYL ETHERS USING 3 -MERCAPTOPROPIONIC ACID

The present application discloses a process for demethylating aromatic methyl ethers by reaction with 3 -mercaptopropionic acid or salts thereof. One preferred example is the demethylation of venlafaxine forming 0 - desmethylvenlafaxine.

Isolation of bright blue fluorescent substances from sonochemical hydroxylation of methyl p-cyanobenzoate

Sonochemical hydroxylation of methyl p-cyanobenzoate (1a) in water gave a bright blue fluorescence, which are mainly ascribed to three new fluorescent compounds, 3-hydroxy, 2,3- and 2,5-dihydroxy derivatives of 1a. Other benzenes substituted with electron-withdrawing groups also gave similar fluorescence from their hydroxylated derivatives. Among the fluorescence substances, methyl 2,5-dihydroxybenzoate was supposed to be applicable for a fluorescent chemosensor.

An efficient one-pot synthesis of nitriles from carboxylic acids without solvent under microwave irradiation

Nitriles were prepared from alkyl and aryl carboxylic acids in dry media conditions, under microwave irradiation. Heating of the carboxylic acid, urea and amidosulfonic acid adsorbed on alumina support in a microwave oven affords nitriles in 20-93% yields.