3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-(2,2,4-trimethyl-[1,3]dioxolan-4-yl)-azulene-1-sulfonic acid butyl ester

Base Information

Chemical Name:3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-(2,2,4-trimethyl-[1,3]dioxolan-4-yl)-azulene-1-sulfonic acid butyl ester
CAS No.:178871-14-2
Molecular Formula:C₃₀H₃₈ClNO₇S₂
Molecular Weight:624.219
Hs Code.:

Synonyms:3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-(2,2,4-trimethyl-[1,3]dioxolan-4-yl)-azulene-1-sulfonic acid butyl ester

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Chemical Property of 3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-(2,2,4-trimethyl-[1,3]dioxolan-4-yl)-azulene-1-sulfonic acid butyl ester

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Technology Process of 3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-(2,2,4-trimethyl-[1,3]dioxolan-4-yl)-azulene-1-sulfonic acid butyl ester

There total 4 articles about 3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-(2,2,4-trimethyl-[1,3]dioxolan-4-yl)-azulene-1-sulfonic acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 67-64-1
acetone

: 178871-13-1
3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-(1,2-dihydroxy-1-methyl-ethyl)-azulene-1-sulfonic acid butyl ester

: 178871-14-2
3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-(2,2,4-trimethyl-[1,3]dioxolan-4-yl)-azulene-1-sulfonic acid butyl ester

Guidance literature:: With toluene-4-sulfonic acid; for 3h; Ambient temperature;
DOI:10.1016/0968-0896(96)00038-7

Reference yield:

: 129648-96-0
3-<4-(4-chlorobenzenesulfonylamino)butyl>-6-isopropylazulene-1-sulfonate

: 178871-14-2
3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-(2,2,4-trimethyl-[1,3]dioxolan-4-yl)-azulene-1-sulfonic acid butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / hexamethylphosphoric acid triamide / 48 h / Ambient temperature

2: 64 percent / O₂, 10percent n-Bu₄NOH in MeOH / tetrahydrofuran / 24 h / Ambient temperature

3: 72 percent / p-TsOH / benzene / 0.33 h / Heating

4: 87 percent / OsO₄, N-methylmorpholine N-oxide*2H₂O / tetrahydrofuran; 2-methyl-propan-2-ol / 18 h / Ambient temperature

5: 93 percent / p-TsOH / 3 h / Ambient temperature

With osmium(VIII) oxide; tetra(n-butyl)ammonium hydroxide; oxygen; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; tert-butyl alcohol; benzene;
DOI:10.1016/0968-0896(96)00038-7

Reference yield:

: 178871-03-9
3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-(1-hydroxy-1-methyl-ethyl)-azulene-1-sulfonic acid butyl ester

: 178871-14-2
3-[4-(4-Chloro-benzenesulfonylamino)-butyl]-6-(2,2,4-trimethyl-[1,3]dioxolan-4-yl)-azulene-1-sulfonic acid butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / p-TsOH / benzene / 0.33 h / Heating

2: 87 percent / OsO₄, N-methylmorpholine N-oxide*2H₂O / tetrahydrofuran; 2-methyl-propan-2-ol / 18 h / Ambient temperature

3: 93 percent / p-TsOH / 3 h / Ambient temperature

With osmium(VIII) oxide; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; tert-butyl alcohol; benzene;
DOI:10.1016/0968-0896(96)00038-7