2,2,2-trichloroethyl(1S,6R,7R)-7-amino-3-benzylceph-3-em-4-carboxylate 1-oxide hydrochloride

Base Information

Chemical Name:2,2,2-trichloroethyl(1S,6R,7R)-7-amino-3-benzylceph-3-em-4-carboxylate 1-oxide hydrochloride
CAS No.:53673-98-6
Molecular Formula:C₁₆H₁₅Cl₃N₂O₄S*ClH
Molecular Weight:474.192
Hs Code.:

Synonyms:2,2,2-trichloroethyl(1S,6R,7R)-7-amino-3-benzylceph-3-em-4-carboxylate 1-oxide hydrochloride

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Chemical Property of 2,2,2-trichloroethyl(1S,6R,7R)-7-amino-3-benzylceph-3-em-4-carboxylate 1-oxide hydrochloride

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Technology Process of 2,2,2-trichloroethyl(1S,6R,7R)-7-amino-3-benzylceph-3-em-4-carboxylate 1-oxide hydrochloride

There total 3 articles about 2,2,2-trichloroethyl(1S,6R,7R)-7-amino-3-benzylceph-3-em-4-carboxylate 1-oxide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

: 53673-97-5
2,2,2-trichloroethyl(1S,6R,7R)-3-benzyl-7-formamidoceph-3-em-4-carboxylate 1-oxide

: 53673-98-6
2,2,2-trichloroethyl(1S,6R,7R)-7-amino-3-benzylceph-3-em-4-carboxylate 1-oxide hydrochloride

Guidance literature:: With trichlorophosphate; In methanol; at 5 ℃; for 1.25h;
DOI:10.1016/S0040-4020(01)88547-1

Reference yield:

: 591-51-5
phenyllithium

: 53673-98-6
2,2,2-trichloroethyl(1S,6R,7R)-7-amino-3-benzylceph-3-em-4-carboxylate 1-oxide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 63.5 percent / cuprous bromide / diethyl ether; benzene; tetrahydrofuran / 3 h / -75 °C

2: 87.5 percent / phosphorus oxychloride / methanol / 1.25 h / 5 °C

With copper(I) bromide; trichlorophosphate; In tetrahydrofuran; methanol; diethyl ether; benzene;
DOI:10.1016/S0040-4020(01)88547-1

Reference yield:

: 33465-56-4
2,2,2-trichloroethyl (1S,6R,7R)-3-bromomethyl-7-formamidoceph-3-em-4-carboxylate 1-oxide

: 53673-98-6
2,2,2-trichloroethyl(1S,6R,7R)-7-amino-3-benzylceph-3-em-4-carboxylate 1-oxide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 63.5 percent / cuprous bromide / diethyl ether; benzene; tetrahydrofuran / 3 h / -75 °C

2: 87.5 percent / phosphorus oxychloride / methanol / 1.25 h / 5 °C

With copper(I) bromide; trichlorophosphate; In tetrahydrofuran; methanol; diethyl ether; benzene;
DOI:10.1016/S0040-4020(01)88547-1