2,2,2-trichloroethyl(1S,6R,7R)-3-benzyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

Base Information

Chemical Name:2,2,2-trichloroethyl(1S,6R,7R)-3-benzyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide
CAS No.:53683-56-0
Molecular Formula:C₂₂H₁₉Cl₃N₂O₅S₂
Molecular Weight:561.894
Hs Code.:

Synonyms:2,2,2-trichloroethyl(1S,6R,7R)-3-benzyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

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Chemical Property of 2,2,2-trichloroethyl(1S,6R,7R)-3-benzyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

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Technology Process of 2,2,2-trichloroethyl(1S,6R,7R)-3-benzyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

There total 4 articles about 2,2,2-trichloroethyl(1S,6R,7R)-3-benzyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.5%

: 39098-97-0
2-thienylacetic acid chloride

: 53673-98-6
2,2,2-trichloroethyl(1S,6R,7R)-7-amino-3-benzylceph-3-em-4-carboxylate 1-oxide hydrochloride

: 53683-56-0
2,2,2-trichloroethyl(1S,6R,7R)-3-benzyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

Guidance literature:: With calcium carbonate; In N,N-dimethyl-formamide; at 5 ℃; for 1.25h;
DOI:10.1016/S0040-4020(01)88547-1

Reference yield:

: 591-51-5
phenyllithium

: 53683-56-0
2,2,2-trichloroethyl(1S,6R,7R)-3-benzyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 63.5 percent / cuprous bromide / diethyl ether; benzene; tetrahydrofuran / 3 h / -75 °C

2: 87.5 percent / phosphorus oxychloride / methanol / 1.25 h / 5 °C

3: 57.5 percent / calcium carbonate / dimethylformamide / 1.25 h / 5 °C

With calcium carbonate; copper(I) bromide; trichlorophosphate; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)88547-1

Reference yield:

: 53673-97-5
2,2,2-trichloroethyl(1S,6R,7R)-3-benzyl-7-formamidoceph-3-em-4-carboxylate 1-oxide

: 53683-56-0
2,2,2-trichloroethyl(1S,6R,7R)-3-benzyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 87.5 percent / phosphorus oxychloride / methanol / 1.25 h / 5 °C

2: 57.5 percent / calcium carbonate / dimethylformamide / 1.25 h / 5 °C

With calcium carbonate; trichlorophosphate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)88547-1