Acetic acid (2R,3S)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Base Information

Chemical Name:Acetic acid (2R,3S)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
CAS No.:130979-52-1
Molecular Formula:C₂₂H₂₅ClN₂O₄S
Molecular Weight:448.971
Hs Code.:

Synonyms:Acetic acid (2R,3S)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

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Chemical Property of Acetic acid (2R,3S)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

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Technology Process of Acetic acid (2R,3S)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

There total 9 articles about Acetic acid (2R,3S)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23474-98-8
2-amino-5-chlorobenzenethiol

: 130979-52-1,111659-76-8
Acetic acid (2R,3S)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 3.9 percent / 16 h / 160 °C

2: 97.7 percent / aq. K₂CO₃ / acetone / 17 h / Heating

3: pyridine / 4 h / 100 °C

With pyridine; potassium carbonate; In acetone;
DOI:10.1021/jm00106a032

Reference yield:

: 96125-49-4
methyl trans-3-(4-methoxyphenyl)glycidate

: 130979-52-1,111659-76-8
Acetic acid (2R,3S)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 3.9 percent / 16 h / 160 °C

2: 97.7 percent / aq. K₂CO₃ / acetone / 17 h / Heating

3: pyridine / 4 h / 100 °C

With pyridine; potassium carbonate; In acetone;
DOI:10.1021/jm00106a032

Reference yield:

: 14371-79-0
2-nitro-5-chlorothiophenol

: 130979-52-1,111659-76-8
Acetic acid (2R,3S)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / NaHCO₃ / ethanol; benzene / 4 h / Ambient temperature

2: 87.6 percent / 10percent NaOH / methanol / 8 h / Ambient temperature

3: 65.6 percent / H₂, AcOH / 10percent Pd/C / ethanol / 11 h / Ambient temperature

4: 78.7 percent / xylene / 24 h / Heating

5: 97.7 percent / aq. K₂CO₃ / acetone / 17 h / Heating

6: pyridine / 4 h / 100 °C

With pyridine; sodium hydroxide; hydrogen; sodium hydrogencarbonate; potassium carbonate; acetic acid; palladium on activated charcoal; In methanol; ethanol; acetone; xylene; benzene;
DOI:10.1021/jm00106a032