Methanesulfonic acid 4-(4-imidazol-1-yl-phenyl)-2-oxo-pyrrolidin-3-ylmethyl ester

Base Information

Chemical Name:Methanesulfonic acid 4-(4-imidazol-1-yl-phenyl)-2-oxo-pyrrolidin-3-ylmethyl ester
CAS No.:1027159-92-7
Molecular Formula:C₁₅H₁₇N₃O₄S
Molecular Weight:335.384
Hs Code.:

Synonyms:Methanesulfonic acid 4-(4-imidazol-1-yl-phenyl)-2-oxo-pyrrolidin-3-ylmethyl ester

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Chemical Property of Methanesulfonic acid 4-(4-imidazol-1-yl-phenyl)-2-oxo-pyrrolidin-3-ylmethyl ester

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Technology Process of Methanesulfonic acid 4-(4-imidazol-1-yl-phenyl)-2-oxo-pyrrolidin-3-ylmethyl ester

There total 5 articles about Methanesulfonic acid 4-(4-imidazol-1-yl-phenyl)-2-oxo-pyrrolidin-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10040-98-9
1-(4-formylphenyl)-1H-imidazole

: 1027159-92-7
Methanesulfonic acid 4-(4-imidazol-1-yl-phenyl)-2-oxo-pyrrolidin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / piperidine, acetic acid / benzene / 28 h / Heating

2: 98 percent / tetramethylguanidine / 2 h / -20 °C

3: 64 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Ambient temperature

4: 98 percent / titanium trichloride, sodium acetate / H₂O; methanol / 2 h

5: calcium chloride, sodium borohydride / methanol / 4 h

6: pyridine / 1.) 0 deg C, 1 h, 2.) from 0 deg C to RT, 3 h

With piperidine; pyridine; sodium tetrahydroborate; titanium(III) chloride; 1,1,3,3-tetramethylguanidine; sodium acetate; ammonium formate; acetic acid; calcium chloride; palladium on activated charcoal; In methanol; water; benzene;
DOI:10.1021/jm00060a012

Reference yield:

: 147471-14-5
2-<<4-(1H-imidazol-1-yl)phenyl>methylene>-1,3-propanedioic acid diethyl ester

: 1027159-92-7
Methanesulfonic acid 4-(4-imidazol-1-yl-phenyl)-2-oxo-pyrrolidin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / tetramethylguanidine / 2 h / -20 °C

2: 64 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Ambient temperature

3: 98 percent / titanium trichloride, sodium acetate / H₂O; methanol / 2 h

4: calcium chloride, sodium borohydride / methanol / 4 h

5: pyridine / 1.) 0 deg C, 1 h, 2.) from 0 deg C to RT, 3 h

With pyridine; sodium tetrahydroborate; titanium(III) chloride; 1,1,3,3-tetramethylguanidine; sodium acetate; ammonium formate; calcium chloride; palladium on activated charcoal; In methanol; water;
DOI:10.1021/jm00060a012

Reference yield:

: 147471-15-6
2<1-<4-(1H-imidazol-1-yl)phenyl>-2-nitroethyl>-1,3-propanedioic acid diethyl ester

: 1027159-92-7
Methanesulfonic acid 4-(4-imidazol-1-yl-phenyl)-2-oxo-pyrrolidin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Ambient temperature

2: 98 percent / titanium trichloride, sodium acetate / H₂O; methanol / 2 h

3: calcium chloride, sodium borohydride / methanol / 4 h

4: pyridine / 1.) 0 deg C, 1 h, 2.) from 0 deg C to RT, 3 h

With pyridine; sodium tetrahydroborate; titanium(III) chloride; sodium acetate; ammonium formate; calcium chloride; palladium on activated charcoal; In methanol; water;
DOI:10.1021/jm00060a012