2-dimethylamino-N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide

Base Information

Chemical Name:2-dimethylamino-N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide
CAS No.:1353968-31-6
Molecular Formula:C₂₆H₂₁FN₆O
Molecular Weight:452.491
Hs Code.:

Synonyms:2-dimethylamino-N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide

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Chemical Property of 2-dimethylamino-N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide

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Technology Process of 2-dimethylamino-N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide

There total 3 articles about 2-dimethylamino-N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353967-37-9
5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine

: 60853-81-8
N,N-dimethylaminoacetyl chloride hydrochloride

: 1353968-31-6
2-dimethylamino-N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide

Guidance literature:: 5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

N,N-dimethylaminoacetyl chloride hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 80935-78-0
1-chloro-[2,6]naphthyridine

: 1353968-31-6
2-dimethylamino-N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium bis(monoperoxyphthalate)hexahydrate / isopropyl alcohol / 40 h / 20 °C

2.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

3.1: methanesulfonyl chloride; pyridine / 16 h / 0 - 20 °C

3.2: 16 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 18 h / 20 °C

With pyridine; magnesium bis(monoperoxyphthalate)hexahydrate; sodium hydride; sodium hydrogencarbonate; methanesulfonyl chloride; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1353969-98-8
1-chloro-[2,6]naphthyridine 6-oxide

: 1353968-31-6
2-dimethylamino-N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

2.1: methanesulfonyl chloride; pyridine / 16 h / 0 - 20 °C

2.2: 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 18 h / 20 °C

With pyridine; sodium hydride; sodium hydrogencarbonate; methanesulfonyl chloride; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide;