diethyl-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-amine

Base Information

Chemical Name:diethyl-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-amine
CAS No.:925204-47-3
Molecular Formula:C₄₂H₅₀N₄O
Molecular Weight:626.885
Hs Code.:

diethyl-(4-{3-[4-(1-trityl-1<i>H</i>-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-amine

Synonyms:diethyl-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-amine

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Chemical Property of diethyl-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-amine

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Technology Process of diethyl-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-amine

There total 4 articles about diethyl-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 151070-87-0
4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine

: 925204-47-3
diethyl-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 110 °C

2: LiAlH₄ / tetrahydrofuran

3: 90 percent / 1,1'-(azodicarbonyl)dipiperidine; Bu₃P / tetrahydrofuran

4: NaBH(OAc)3 / CH₂Cl₂

With lithium aluminium tetrahydride; tributylphosphine; sodium tris(acetoxy)borohydride; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.10.087

Reference yield:

: 877142-02-4
3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-ol

: 925204-47-3
diethyl-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 1,1'-(azodicarbonyl)dipiperidine; Bu₃P / tetrahydrofuran

2: NaBH(OAc)3 / CH₂Cl₂

With tributylphosphine; sodium tris(acetoxy)borohydride; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.10.087

Reference yield:

: 224168-91-6
3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propionic acid methyl ester

: 925204-47-3
diethyl-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄ / tetrahydrofuran

2: 90 percent / 1,1'-(azodicarbonyl)dipiperidine; Bu₃P / tetrahydrofuran

3: NaBH(OAc)3 / CH₂Cl₂

With lithium aluminium tetrahydride; tributylphosphine; sodium tris(acetoxy)borohydride; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.10.087