877142-02-4

Upstream product

• 224168-76-7 acetic acid pyridin-4-yl-(1-trityl-1H-imidazol-4-yl)-methyl ester 
• 151070-87-0 4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine 
• 872-85-5 pyridine-4-carbaldehyde 
• 96797-15-8 N-trityl-4⁽⁵⁾-iodoimidazole 
• 224168-75-6 pyridin-4-yl-(1-trityl-1H-imidazol-4-yl)methanol 
• 224168-91-6 3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propionic acid methyl ester 

Downstream Products

• 925439-00-5 4-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 925426-15-9 N-cyclohexyl-2,2,2-trifluoro-N-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-phenyl)-acetamide 
• 925425-69-0 1-[3-(4-Piperidin-1-yl-phenoxy)-propyl]-4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine 
• 925431-16-9 6-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-quinoline 
• 925204-31-5 1-[3-(4-Piperidin-1-ylmethyl-phenoxy)-propyl]-4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine 
• 925420-69-5 1-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propyl]-4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine 
• 925438-96-6 piperidin-1-yl-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-phenyl)-methanone 
• 925425-58-7 1-[3-(4-cyclohexyloxy-phenoxy)-propyl]-4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidine 
• 877142-03-5 4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzaldehyde 
• 925436-68-6 5-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-phenyl)-pyrimidine 
• 925204-63-3 1'-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-[1,4']bipiperidinyl 
• 925204-62-2 1-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-piperidine-4-carboxylic acid amide 
• 925443-86-3 4,4-Difluoro-1-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-piperidine 
• 925204-47-3 diethyl-(4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzyl)-amine 

Relevant academic research and scientific papers

Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold

We report the discovery of novel histamine H3 receptor antagonists based on 4-[(1H-imidazol-4-yl)methyl]piperidine. The most potent compounds in the series (e.g., 7) result from the attachment of a substituted aniline amide to the main pharmaco

Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl] piperidine series of histamine H3 receptor antagonists

A novel series of histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine template displaying low CYP2D6 and CYP3A4 inhibitory profiles has been identified. Structural features responsible for the reduction of P450 activity, a typical liability of 4-substituted imidazoles, have been established.