1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid cyclopropylamide

Base Information

Chemical Name:1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid cyclopropylamide
CAS No.:1401102-82-6
Molecular Formula:C₂₃H₁₈Cl₄F₃N₃O₂
Molecular Weight:567.222
Hs Code.:

Synonyms:1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid cyclopropylamide

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Chemical Property of 1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid cyclopropylamide

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Technology Process of 1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid cyclopropylamide

There total 6 articles about 1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid cyclopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1401102-98-4
1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid

: 765-30-0
Cyclopropylamine

: 1401102-82-6
1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid cyclopropylamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1401102-82-6
1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid cyclopropylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dimethyl sulfoxide / 24 h / 20 - 100 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 2 h / 0 - 20 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / water; methanol / 3 h / 0 - 20 °C

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.5 h / 20 - 45 °C

4.2: 18 h / 20 °C / Inert atmosphere

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 18 h / 20 °C

5.2: pH ~ 5

6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere

With N-chloro-succinimide; hydroxylamine hydrochloride; water; sodium acetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1401102-94-0
1-[4-(hydroxyiminomethyl)phenyl]azetidine-3-carboxylic acid methyl ester

: 1401102-82-6
1-{2-chloro-4-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}azetidine-3-carboxylic acid cyclopropylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.5 h / 20 - 45 °C

1.2: 18 h / 20 °C / Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 18 h / 20 °C

2.2: pH ~ 5

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere

With N-chloro-succinimide; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;