(3S,7S,8aR)-7-Butyl-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Base Information

• Chemical Name: (3S,7S,8aR)-7-Butyl-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
• CAS No.: 258286-08-7
• Molecular Formula: C₁₈H₂₅NO₂
• Molecular Weight: 287.402
• Mol file: 258286-08-7.mol

Synonyms:(3S,7S,8aR)-7-Butyl-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Chemical Property of (3S,7S,8aR)-7-Butyl-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,7S,8aR)-7-Butyl-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

There total 2 articles about (3S,7S,8aR)-7-Butyl-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

1-iodo-butane (542-69-8) + 8a-methyl-3-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine-5-carbonitrile (258286-06-5) → (3S,7S,8aR)-7-Butyl-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one (258286-08-7)

Guidance literature:

8a-methyl-3-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine-5-carbonitrile; With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; at -78 ℃;

1-iodo-butane;

With hydrogenchloride; In tetrahydrofuran; Acid hydrolysis;

DOI:10.1016/S0040-4039(99)01784-0

Reference yield:

(3S,8aR)-8a-Methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-thione → (3S,7S,8aR)-7-Butyl-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one (258286-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃OBF₄ / CH₂Cl₂

1.2: 70 percent / CuI; I₂

2.1: LiTMP; HMPA / tetrahydrofuran / -78 °C

2.3: 56 percent / aq. HCl / tetrahydrofuran / Acid hydrolysis

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2,6,6-tetramethylpiperidinyl-lithium; triethyloxonium fluoroborate; In tetrahydrofuran; dichloromethane; 1.1: Rearrangement / 1.2: Substitution / 2.1: Metallation / 2.2: Alkylation / 2.3: Hydrolysis;

DOI:10.1016/S0040-4039(99)01784-0

Reference yield:

(3S,7S,8aR)-7-Butyl-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one (258286-08-7) → (3S,7R,8aR)-7-Butyl-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0040-4039(99)01784-0

upstream raw materials:

1-iodo-butane

8a-methyl-3-phenyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridine-5-carbonitrile