(Z)-Methyl 4-<2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-3,3,3-trifluoro-1-propenyl>benzoate

Base Information

• Chemical Name: (Z)-Methyl 4-<2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-3,3,3-trifluoro-1-propenyl>benzoate
• CAS No.: 119436-38-3
• Molecular Formula: C₂₅H₂₇F₃O₂
• Molecular Weight: 416.483

Synonyms:(Z)-Methyl 4-<2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-3,3,3-trifluoro-1-propenyl>benzoate

Chemical Property of (Z)-Methyl 4-<2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-3,3,3-trifluoro-1-propenyl>benzoate

Chemical Property:

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Technology Process of (Z)-Methyl 4-<2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-3,3,3-trifluoro-1-propenyl>benzoate

There total 2 articles about (Z)-Methyl 4-<2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-3,3,3-trifluoro-1-propenyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene (27452-17-1) → (Z)-Methyl 4-<2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-3,3,3-trifluoro-1-propenyl>benzoate (119436-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) sec-BuLi / 1) ether, cyclohexane, r.t., 30 min, 2) ether, reflux, 2 h

2: acetonitrile / 2 h / Heating

With sec.-butyllithium; In acetonitrile;

DOI:10.1021/jm00125a027

Reference yield:

4-methoxycarbonylbenzyltriphenylphosphonium bromide (1253-46-9) + 5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl trifluoromethyl ketone (119436-37-2) → (E)-Methyl 4-<2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-3,3,3-trifluoro-1-propenyl>benzoate (119436-39-4) + (Z)-Methyl 4-<2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-3,3,3-trifluoro-1-propenyl>benzoate (119436-38-3)

Guidance literature:

In acetonitrile; for 2h; Yield given. Yields of byproduct given; Heating;

DOI:10.1021/jm00125a027

Reference yield:

(Z)-Methyl 4-<2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-3,3,3-trifluoro-1-propenyl>benzoate (119436-38-3) → (Z)-4-<2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-3,3,3-trifluoro-1-propenyl>benzoic acid (119435-85-7)

Guidance literature:

With sodium hydroxide; In ethanol; at 70 ℃; for 2h;

DOI:10.1021/jm00125a027

upstream raw materials:

4-methoxycarbonylbenzyltriphenylphosphonium bromide

5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl trifluoromethyl ketone

6-bromo-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene

Downstream raw materials:

(Z)-4-<2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-3,3,3-trifluoro-1-propenyl>benzoic acid

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