methyl-(S)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)-3-phenylpropanoic acid

Base Information

Chemical Name:methyl-(S)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)-3-phenylpropanoic acid
CAS No.:1446253-08-2
Molecular Formula:C₂₀H₁₇ClN₂O₄
Molecular Weight:384.819
Hs Code.:

Synonyms:methyl-(S)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)-3-phenylpropanoic acid

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Chemical Property of methyl-(S)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)-3-phenylpropanoic acid

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Technology Process of methyl-(S)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)-3-phenylpropanoic acid

There total 3 articles about methyl-(S)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 223388-21-4
1-chloro-4-hydroxyisoquinoline-3-carboxylic acid

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 1446253-08-2
methyl-(S)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)-3-phenylpropanoic acid

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1021/jm400193d

Reference yield:

: 223388-21-4
1-chloro-4-hydroxyisoquinoline-3-carboxylic acid

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 1446253-08-2
methyl-(S)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)-3-phenylpropanoic acid

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/jm400769b

Reference yield:

: 223388-20-3
methyl 1-chloro-4-hydroxyisoquinoline-3-carboxylate

: 1446253-08-2
methyl-(S)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 24 h / 20 °C

1.2: pH 1

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400769b