N-({3-[(3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-hydroxy-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Base Information

Chemical Name:N-({3-[(3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-hydroxy-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide
CAS No.:1240516-86-2
Molecular Formula:C₂₁H₁₉ClN₄O₄S₂
Molecular Weight:490.991
Hs Code.:

Synonyms:N-({3-[(3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-hydroxy-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

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Chemical Property of N-({3-[(3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-hydroxy-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

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Technology Process of N-({3-[(3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-hydroxy-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

There total 5 articles about N-({3-[(3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-hydroxy-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1240518-17-5
N-(1-{[3-(aminomethyl)phenyl]methyl}-4-hydroxy-1H-indazol-3-yl)-5-chloro-2-thiophenesulfonamide formate

: 64-19-7,77671-22-8
acetic acid

: 1240516-86-2
N-({3-[(3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-hydroxy-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 140675-43-0
2-Fluoro-6-hydroxybenzonitrile

: 1240516-86-2
N-({3-[(3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-hydroxy-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrazine hydrate / ethanol / 4 h / 90 °C / Inert atmosphere

2: potassium hydroxide / dimethyl sulfoxide / 0.42 h / 20 °C / Inert atmosphere

3: pyridine / 0.67 h / 20 °C / Inert atmosphere

4: lithium aluminium tetrahydride; hydrogenchloride / diethyl ether; tetrahydrofuran / 1 h / 10 - 20 °C / Inert atmosphere

5: boron tribromide / methanol; dichloromethane / 2.5 h / 20 °C / Inert atmosphere

6: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; boron tribromide; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm301572h

Reference yield:

: 88805-68-9
3-amino-4-hydroxyindazole

: 1240516-86-2
N-({3-[(3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-hydroxy-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / dimethyl sulfoxide / 0.42 h / 20 °C / Inert atmosphere

2: pyridine / 0.67 h / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride; hydrogenchloride / diethyl ether; tetrahydrofuran / 1 h / 10 - 20 °C / Inert atmosphere

4: boron tribromide / methanol; dichloromethane / 2.5 h / 20 °C / Inert atmosphere

5: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; boron tribromide; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm301572h