9-{(1R,2R,3S)-3-benzoyloxymethyl-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]cyclobut-1-yl}adenine

Base Information

Chemical Name:9-{(1R,2R,3S)-3-benzoyloxymethyl-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]cyclobut-1-yl}adenine
CAS No.:946392-58-1
Molecular Formula:C₂₂H₂₅N₅O₄
Molecular Weight:423.472
Hs Code.:

Synonyms:9-{(1R,2R,3S)-3-benzoyloxymethyl-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]cyclobut-1-yl}adenine

Suppliers and Price of 9-{(1R,2R,3S)-3-benzoyloxymethyl-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]cyclobut-1-yl}adenine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 9-{(1R,2R,3S)-3-benzoyloxymethyl-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]cyclobut-1-yl}adenine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-{(1R,2R,3S)-3-benzoyloxymethyl-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]cyclobut-1-yl}adenine

There total 11 articles about 9-{(1R,2R,3S)-3-benzoyloxymethyl-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]cyclobut-1-yl}adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 946392-57-0
{(1S,2S,3S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-(methylsulfonyloxy)cyclobutyl}methyl benzoate

: 73-24-5,71660-29-2,71660-30-5
7H-purin-6-ylamine

: 946392-58-1
9-{(1R,2R,3S)-3-benzoyloxymethyl-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]cyclobut-1-yl}adenine

: 7-{(1R,2R,3S)-3-benzoyloxymethyl-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]cyclobut-1-yl}adenine

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 7h;
DOI:10.1021/ol0710616

Reference yield:

: 946392-55-8
{(1S,2S,3S)-3-tert-butyldiphenylsilyloxy-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]cyclobutyl}methanol

: 946392-58-1
9-{(1R,2R,3S)-3-benzoyloxymethyl-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]cyclobut-1-yl}adenine

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂

2: 97 percent / TBAF / tetrahydrofuran / 2 h

3: 93 percent / Et₃N / CH₂Cl₂ / 1.5 h / 20 °C

4: 45 percent / K₂CO₃; 18-crown-6 / dimethylformamide / 7 h / 120 °C

With pyridine; dmap; 18-crown-6 ether; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0710616

Reference yield:

: 946392-51-4
(1R,4S,5S,6S)-6-tert-butyldiphenylsilyloxy-4-pivaloyloxymethyl-3-oxabicyclo[3.2.0]heptan-2-one

: 946392-58-1
9-{(1R,2R,3S)-3-benzoyloxymethyl-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]cyclobut-1-yl}adenine

Guidance literature:: Multi-step reaction with 8 steps

1.1: 88 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

2.1: 82 percent / sodium sulphate; copper sulphate; aq. HCl / 12 h

3.1: 85 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

4.1: sodium carbonate / methanol / 4 h

4.2: 88 percent / NaBH₄ / methanol / 0.33 h

5.1: 86 percent / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂

6.1: 97 percent / TBAF / tetrahydrofuran / 2 h

7.1: 93 percent / Et₃N / CH₂Cl₂ / 1.5 h / 20 °C

8.1: 45 percent / K₂CO₃; 18-crown-6 / dimethylformamide / 7 h / 120 °C

With pyridine; hydrogenchloride; dmap; lithium aluminium tetrahydride; copper(I) sulfate; 18-crown-6 ether; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; Dess-Martin periodane; sodium sulfate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0710616