cyclo-

Base Information

Chemical Name:cyclo-
CAS No.:127819-91-4
Molecular Formula:C₄₁H₅₃N₇O₆
Molecular Weight:739.915
Hs Code.:

cyclo-<D-Phe-L-Ile-D-Δ-Piz-L-Pip-D-(N-Me)Phe-L-Pro>

Synonyms:cyclo-

Suppliers and Price of cyclo-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cyclo-

Chemical Property:

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Technology Process of cyclo-

There total 25 articles about cyclo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: cyclo-

: 127819-91-4
cyclo-

Guidance literature:: With pyridine; tert-butylhypochlorite; at 0 ℃; for 1.5h;
DOI:10.1021/jm00099a019

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 127819-91-4
cyclo-

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluoropfosphate (BOP reagent), N,N-diisopropylethylamine (DIEA) / acetonitrile / Ambient temperature

2: H₂ / 20percent Pd(OH)2/C / methanol / 16 h / 2844.3 Torr

3: NaHCO₃, diphenylphosphoryl azide (DPPA) / dimethylformamide / 48 h / 0 - 5 °C

4: 26 percent / pyridine, tert-butyl hypochlorite / 1.5 h / 0 °C

With pyridine; tert-butylhypochlorite; diphenylphosphoranyl azide; hydrogen; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00099a019

Reference yield:

: H-L-Pip-D-(N-Me)Phe-L-Pro-OCH₂Ph

: 127819-91-4
cyclo-

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / aq. Na₂CO₃ / CH₂Cl₂ / 2 h / pH 8

2: diethylamine / acetonitrile / Ambient temperature

3: 55 percent / AgCN / toluene / 0.5 h / 80 - 85 °C

4: diethylamine / acetonitrile / Ambient temperature

5: 76 percent / benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluoropfosphate (BOP reagent), N,N-diisopropylethylamine (DIEA) / acetonitrile / Ambient temperature

6: H₂ / 20percent Pd(OH)2/C / methanol / 16 h / 2844.3 Torr

7: NaHCO₃, diphenylphosphoryl azide (DPPA) / dimethylformamide / 48 h / 0 - 5 °C

8: 26 percent / pyridine, tert-butyl hypochlorite / 1.5 h / 0 °C

With pyridine; silver cyanide; tert-butylhypochlorite; diphenylphosphoranyl azide; hydrogen; sodium hydrogencarbonate; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm00099a019