(3aR,7R,7aR)-4,4-diphenyl-7-fluoro-2-tert-butyloxycarbonylperhydroisoindole

Base Information

• Chemical Name: (3aR,7R,7aR)-4,4-diphenyl-7-fluoro-2-tert-butyloxycarbonylperhydroisoindole
• CAS No.: 146402-78-0
• Molecular Formula: C₂₅H₃₀FNO₂
• Molecular Weight: 395.517
• Mol file: 146402-78-0.mol

Synonyms:(3aR,7R,7aR)-4,4-diphenyl-7-fluoro-2-tert-butyloxycarbonylperhydroisoindole

Chemical Property of (3aR,7R,7aR)-4,4-diphenyl-7-fluoro-2-tert-butyloxycarbonylperhydroisoindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aR,7R,7aR)-4,4-diphenyl-7-fluoro-2-tert-butyloxycarbonylperhydroisoindole

There total 10 articles about (3aR,7R,7aR)-4,4-diphenyl-7-fluoro-2-tert-butyloxycarbonylperhydroisoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(3aR,7S,7aR)-7-Hydroxy-4,4-diphenyl-octahydro-isoindole-2-carboxylic acid tert-butyl ester (146402-73-5) → (3aR,7R,7aR)-4,4-diphenyl-7-fluoro-2-tert-butyloxycarbonylperhydroisoindole (146402-78-0)

Guidance literature:

With Nonafluorobutanesulfonyl fluoride; diethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/0040-4039(96)01760-1

Reference yield:

(3AR,7S,7AR)-2-t-butoxy-carbonyl-4,4-diphenyl-7-trifluoromethylsulphonyloxy-perhydroisoindole → (3aR,7R,7aR)-4,4-diphenyl-7-fluoro-2-tert-butyloxycarbonylperhydroisoindole (146402-78-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;

Reference yield:

(3AR,4S,7AR)-2-t-butoxycarbonyl-7,7-diphenyl-4-perhydroisoindolol + morpholinosulphur trifluoride → (3aR,7R,7aR)-4,4-diphenyl-7-fluoro-2-tert-butyloxycarbonylperhydroisoindole (146402-78-0)

Guidance literature:

With sodium bicarbonate; In dichloromethane;

upstream raw materials:

(3aR,7S,7aR)-7-Hydroxy-4,4-diphenyl-octahydro-isoindole-2-carboxylic acid tert-butyl ester

1,1-diphenylacetone

4,4-diphenyl-2-cyclohexen-1-one

4,4-diphenylcyclohexane-1,3-dione

Downstream raw materials:

1-((3aR,7R,7aR)-7-Fluoro-4,4-diphenyl-octahydro-isoindol-2-yl)-2-[2-(3-pyrrolidin-1-yl-propoxy)-phenyl]-ethanone

(3aR,7R,7aR)-7-Fluoro-4,4-diphenyl-octahydro-isoindole