(3aR,7S,7aR)-7-Hydroxy-4,4-diphenyl-octahydro-isoindole-2-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (3aR,7S,7aR)-7-Hydroxy-4,4-diphenyl-octahydro-isoindole-2-carboxylic acid tert-butyl ester
• CAS No.: 146402-73-5
• Molecular Formula: C₂₅H₃₁NO₃
• Molecular Weight: 393.526
• Mol file: 146402-73-5.mol

Synonyms:(3aR,7S,7aR)-7-Hydroxy-4,4-diphenyl-octahydro-isoindole-2-carboxylic acid tert-butyl ester

Chemical Property of (3aR,7S,7aR)-7-Hydroxy-4,4-diphenyl-octahydro-isoindole-2-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aR,7S,7aR)-7-Hydroxy-4,4-diphenyl-octahydro-isoindole-2-carboxylic acid tert-butyl ester

There total 5 articles about (3aR,7S,7aR)-7-Hydroxy-4,4-diphenyl-octahydro-isoindole-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-diphenylacetone (781-35-1) → (3aR,7S,7aR)-7-Hydroxy-4,4-diphenyl-octahydro-isoindole-2-carboxylic acid tert-butyl ester (146402-73-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 98 percent / t-BuOK / various solvent(s) / 20 °C

2: PTSA / toluene

3: Red-Al / toluene / 0 - 20 °C

4: 70 percent / CF₃COOH / toluene / 35 °C

5: H₂ / Pd/C (5percent) / butan-1-ol; acetic acid / 20 °C

6: 1.) NaBH₄ / 1.) aq. NaOH / 1.) MeOH, -20 deg C; 2.) MeOH

With sodium tetrahydroborate; potassium tert-butylate; hydrogen; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium hydroxide; palladium on activated charcoal; toluene-4-sulfonic acid; trifluoroacetic acid; In acetic acid; toluene; butan-1-ol;

DOI:10.1016/0040-4039(96)01760-1

Reference yield:

4,4-diphenyl-2-cyclohexen-1-one (4528-64-7) → (3aR,7S,7aR)-7-Hydroxy-4,4-diphenyl-octahydro-isoindole-2-carboxylic acid tert-butyl ester (146402-73-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / CF₃COOH / toluene / 35 °C

2: H₂ / Pd/C (5percent) / butan-1-ol; acetic acid / 20 °C

3: 1.) NaBH₄ / 1.) aq. NaOH / 1.) MeOH, -20 deg C; 2.) MeOH

With sodium tetrahydroborate; hydrogen; sodium hydroxide; palladium on activated charcoal; trifluoroacetic acid; In acetic acid; toluene; butan-1-ol;

DOI:10.1016/0040-4039(96)01760-1

Reference yield:

4,4-diphenylcyclohexane-1,3-dione (13128-74-0) → (3aR,7S,7aR)-7-Hydroxy-4,4-diphenyl-octahydro-isoindole-2-carboxylic acid tert-butyl ester (146402-73-5)

Guidance literature:

Multi-step reaction with 5 steps

1: PTSA / toluene

2: Red-Al / toluene / 0 - 20 °C

3: 70 percent / CF₃COOH / toluene / 35 °C

4: H₂ / Pd/C (5percent) / butan-1-ol; acetic acid / 20 °C

5: 1.) NaBH₄ / 1.) aq. NaOH / 1.) MeOH, -20 deg C; 2.) MeOH

With sodium tetrahydroborate; hydrogen; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium hydroxide; palladium on activated charcoal; toluene-4-sulfonic acid; trifluoroacetic acid; In acetic acid; toluene; butan-1-ol;

DOI:10.1016/0040-4039(96)01760-1

upstream raw materials:

1,1-diphenylacetone

4,4-diphenyl-2-cyclohexen-1-one

4,4-diphenylcyclohexane-1,3-dione

Downstream raw materials:

1-((3aR,7R,7aR)-7-Fluoro-4,4-diphenyl-octahydro-isoindol-2-yl)-2-[2-(3-pyrrolidin-1-yl-propoxy)-phenyl]-ethanone

(3aR,7R,7aR)-7-Fluoro-4,4-diphenyl-octahydro-isoindole

(3aR,7R,7aR)-4,4-diphenyl-7-fluoro-2-tert-butyloxycarbonylperhydroisoindole