(2R,3S)-3-benzyl 1,1-diethyl 2-(4-methoxyphenyl)-3-(diphenylmethyleneamino)propane-1,1,3-tricarboxylate

Base Information

Chemical Name:(2R,3S)-3-benzyl 1,1-diethyl 2-(4-methoxyphenyl)-3-(diphenylmethyleneamino)propane-1,1,3-tricarboxylate
CAS No.:1312929-71-7
Molecular Formula:C₃₇H₃₇NO₇
Molecular Weight:607.703
Hs Code.:

Synonyms:(2R,3S)-3-benzyl 1,1-diethyl 2-(4-methoxyphenyl)-3-(diphenylmethyleneamino)propane-1,1,3-tricarboxylate

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Chemical Property of (2R,3S)-3-benzyl 1,1-diethyl 2-(4-methoxyphenyl)-3-(diphenylmethyleneamino)propane-1,1,3-tricarboxylate

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Technology Process of (2R,3S)-3-benzyl 1,1-diethyl 2-(4-methoxyphenyl)-3-(diphenylmethyleneamino)propane-1,1,3-tricarboxylate

There total 1 articles about (2R,3S)-3-benzyl 1,1-diethyl 2-(4-methoxyphenyl)-3-(diphenylmethyleneamino)propane-1,1,3-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 6768-23-6
diethyl-2-(4-methoxybenzylidene)malonate

: 81477-91-0
benzyl 2-(diphenylmethyleneamino)acetate

: 1312929-71-7
(2R,3S)-3-benzyl 1,1-diethyl 2-(4-methoxyphenyl)-3-(diphenylmethyleneamino)propane-1,1,3-tricarboxylate

Guidance literature:: With tetrakis(actonitrile)copper(I) hexafluorophosphate; (Rp)-2-(tert-butylthio)-1-(diphenyl-phosphino)ferrocene; caesium carbonate; In tetrahydrofuran; at -10 ℃; for 12h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201100374

Reference yield:

: 1312929-71-7
(2R,3S)-3-benzyl 1,1-diethyl 2-(4-methoxyphenyl)-3-(diphenylmethyleneamino)propane-1,1,3-tricarboxylate

: C₂₄H₂₉NO₇

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1002/chem.201100374

Reference yield:

: 1312929-71-7
(2R,3S)-3-benzyl 1,1-diethyl 2-(4-methoxyphenyl)-3-(diphenylmethyleneamino)propane-1,1,3-tricarboxylate

: 1312929-55-7
(2S,3R,4S)-4-(ethoxycarbonyl)-3-(4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: potassium carbonate / tetrahydrofuran; water; ethyl acetate / 0 °C / Inert atmosphere

3: 30% Pd/C; hydrogen / ethanol / 1 h / 20 °C / 760.05 Torr

With hydrogenchloride; 30% Pd/C; water; hydrogen; potassium carbonate; In tetrahydrofuran; ethanol; water; ethyl acetate;
DOI:10.1002/chem.201100374