(2S,3R,4S)-4-(ethoxycarbonyl)-3-(4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(2S,3R,4S)-4-(ethoxycarbonyl)-3-(4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid
CAS No.:1312929-55-7
Molecular Formula:C₁₅H₁₇NO₆
Molecular Weight:307.303
Hs Code.:

Synonyms:(2S,3R,4S)-4-(ethoxycarbonyl)-3-(4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid

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Chemical Property of (2S,3R,4S)-4-(ethoxycarbonyl)-3-(4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid

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Technology Process of (2S,3R,4S)-4-(ethoxycarbonyl)-3-(4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid

There total 4 articles about (2S,3R,4S)-4-(ethoxycarbonyl)-3-(4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1312929-85-3
(2S,3R,4S)-2-benzyl 4-ethyl 3-(4-methoxyphenyl)-5-oxopyrrolidine-2,4-dicarboxylate

: 1312929-55-7
(2S,3R,4S)-4-(ethoxycarbonyl)-3-(4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid

Guidance literature:: With 30% Pd/C; hydrogen; In ethanol; at 20 ℃; for 1h; under 760.051 Torr;
DOI:10.1002/chem.201100374

Reference yield:

: 1312929-71-7
(2R,3S)-3-benzyl 1,1-diethyl 2-(4-methoxyphenyl)-3-(diphenylmethyleneamino)propane-1,1,3-tricarboxylate

: 1312929-55-7
(2S,3R,4S)-4-(ethoxycarbonyl)-3-(4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: potassium carbonate / tetrahydrofuran; water; ethyl acetate / 0 °C / Inert atmosphere

3: 30% Pd/C; hydrogen / ethanol / 1 h / 20 °C / 760.05 Torr

With hydrogenchloride; 30% Pd/C; water; hydrogen; potassium carbonate; In tetrahydrofuran; ethanol; water; ethyl acetate;
DOI:10.1002/chem.201100374

Reference yield:

: 6768-23-6
diethyl-2-(4-methoxybenzylidene)malonate

: 1312929-55-7
(2S,3R,4S)-4-(ethoxycarbonyl)-3-(4-methoxyphenyl)-5-oxopyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(actonitrile)copper(I) hexafluorophosphate; (Rp)-2-(tert-butylthio)-1-(diphenyl-phosphino)ferrocene; caesium carbonate / tetrahydrofuran / 12 h / -10 °C / Inert atmosphere

2: hydrogenchloride; water / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3: potassium carbonate / tetrahydrofuran; water; ethyl acetate / 0 °C / Inert atmosphere

4: 30% Pd/C; hydrogen / ethanol / 1 h / 20 °C / 760.05 Torr

With hydrogenchloride; tetrakis(actonitrile)copper(I) hexafluorophosphate; (Rp)-2-(tert-butylthio)-1-(diphenyl-phosphino)ferrocene; 30% Pd/C; water; hydrogen; potassium carbonate; caesium carbonate; In tetrahydrofuran; ethanol; water; ethyl acetate;
DOI:10.1002/chem.201100374