(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (2S)-(4-isopropylphenyl)[(2-methyl-3-oxo-5,7-dipropyl-2,3-dihydro-1,2-benzisoxazol-6-yl)oxy]acetate

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Chemical Name:(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (2S)-(4-isopropylphenyl)[(2-methyl-3-oxo-5,7-dipropyl-2,3-dihydro-1,2-benzisoxazol-6-yl)oxy]acetate
CAS No.:860780-53-6
Molecular Formula:C₃₂H₄₂N₂O₆
Molecular Weight:550.695
Hs Code.:

Synonyms:(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (2S)-(4-isopropylphenyl)[(2-methyl-3-oxo-5,7-dipropyl-2,3-dihydro-1,2-benzisoxazol-6-yl)oxy]acetate

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Chemical Property of (1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (2S)-(4-isopropylphenyl)[(2-methyl-3-oxo-5,7-dipropyl-2,3-dihydro-1,2-benzisoxazol-6-yl)oxy]acetate

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Technology Process of (1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (2S)-(4-isopropylphenyl)[(2-methyl-3-oxo-5,7-dipropyl-2,3-dihydro-1,2-benzisoxazol-6-yl)oxy]acetate

There total 10 articles about (1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (2S)-(4-isopropylphenyl)[(2-methyl-3-oxo-5,7-dipropyl-2,3-dihydro-1,2-benzisoxazol-6-yl)oxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 449779-69-5
6-hydroxy-2-methyl-5,7-dipropyl-1,2-benzisoxazol-3(2H)-one

: 449779-79-7
(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl bromo(4-isopropylphenyl)acetate

: 860780-53-6
(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (2S)-(4-isopropylphenyl)[(2-methyl-3-oxo-5,7-dipropyl-2,3-dihydro-1,2-benzisoxazol-6-yl)oxy]acetate

Guidance literature:: 6-hydroxy-2-methyl-5,7-dipropyl-1,2-benzisoxazol-3(2H)-one; With lithium tert-butoxide; In tetrahydrofuran; at 0 ℃;

(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl bromo(4-isopropylphenyl)acetate; In tetrahydrofuran; at 0 ℃;
DOI:10.1021/jm0502135

Reference yield:

: 860780-50-3
methyl 2,4-bis(allyloxy)benzoate

: 860780-53-6
(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (2S)-(4-isopropylphenyl)[(2-methyl-3-oxo-5,7-dipropyl-2,3-dihydro-1,2-benzisoxazol-6-yl)oxy]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 81 percent / various solvent(s) / 7 h / Heating

2.1: H₂ / Pd/C / ethyl acetate / 6 h / 760 Torr

2.2: 83 percent / aq. NaOH / methanol / 16 h / Heating

3.1: pyridine / CH₂Cl₂ / 1 h / 0 - 25 °C

3.2: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / Heating

3.3: 65 percent / aq. Na₂CO₃ / diethyl ether; CH₂Cl₂ / 0.5 h

4.1: Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 0.5 h / 25 °C

4.2: 86 percent / aq. NaOH / methanol / 0.5 h

5.1: t-BuOLi / tetrahydrofuran / 0 °C

5.2: 95 percent / tetrahydrofuran / 0 °C

With pyridine; hydrogen; triphenylphosphine; lithium tert-butoxide; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; 4.1: Mitsunobu reaction;
DOI:10.1021/jm0502135

Reference yield:

: 449779-66-2
methyl 2,4-dihydroxy-3,5-diallylbenzoate

: 860780-53-6
(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (2S)-(4-isopropylphenyl)[(2-methyl-3-oxo-5,7-dipropyl-2,3-dihydro-1,2-benzisoxazol-6-yl)oxy]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂ / Pd/C / ethyl acetate / 6 h / 760 Torr

1.2: 83 percent / aq. NaOH / methanol / 16 h / Heating

2.1: pyridine / CH₂Cl₂ / 1 h / 0 - 25 °C

2.2: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / Heating

2.3: 65 percent / aq. Na₂CO₃ / diethyl ether; CH₂Cl₂ / 0.5 h

3.1: Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 0.5 h / 25 °C

3.2: 86 percent / aq. NaOH / methanol / 0.5 h

4.1: t-BuOLi / tetrahydrofuran / 0 °C

4.2: 95 percent / tetrahydrofuran / 0 °C

With pyridine; hydrogen; triphenylphosphine; lithium tert-butoxide; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; 3.1: Mitsunobu reaction;
DOI:10.1021/jm0502135