(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl bromo(4-isopropylphenyl)acetate

Base Information

Chemical Name:(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl bromo(4-isopropylphenyl)acetate
CAS No.:449779-79-7
Molecular Formula:C₁₈H₂₄BrNO₃
Molecular Weight:382.297
Hs Code.:

Synonyms:(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl bromo(4-isopropylphenyl)acetate

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Chemical Property of (1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl bromo(4-isopropylphenyl)acetate

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Technology Process of (1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl bromo(4-isopropylphenyl)acetate

There total 4 articles about (1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl bromo(4-isopropylphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 449779-80-0
(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (4-isopropylphenyl)(oxo)acetate

: 449779-79-7
(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl bromo(4-isopropylphenyl)acetate

Guidance literature:: (1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (4-isopropylphenyl)(oxo)acetate; With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 0.5h;

With phosphorus tribromide; In dichloromethane; at 25 ℃; for 0.5h;
DOI:10.1021/jm0502135

Reference yield:

: 98-82-8
Isopropylbenzene

: 449779-79-7
(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl bromo(4-isopropylphenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: AlCl₃ / CH₂Cl₂ / 2 h / 25 °C

1.2: aq. NaOH / methanol / 0.5 h

2.1: oxalyl chloride; DMF / CH₂Cl₂ / 0.5 h / Heating

2.2: 80 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 - 25 °C

3.1: NaBH₄ / tetrahydrofuran / 0.5 h / 0 °C

3.2: 82 percent / PBr₃ / CH₂Cl₂ / 0.5 h / 25 °C

With sodium tetrahydroborate; aluminium trichloride; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0502135

Reference yield:

: 51208-83-4
2-(4-isopropylphenyl)-2-oxoacetic acid

: 449779-79-7
(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl bromo(4-isopropylphenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl chloride; DMF / CH₂Cl₂ / 0.5 h / Heating

1.2: 80 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 - 25 °C

2.1: NaBH₄ / tetrahydrofuran / 0.5 h / 0 °C

2.2: 82 percent / PBr₃ / CH₂Cl₂ / 0.5 h / 25 °C

With sodium tetrahydroborate; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0502135