methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(N-methoxyamino)pyrrolidine-(2R)-carboxylate

Base Information

Chemical Name:methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(N-methoxyamino)pyrrolidine-(2R)-carboxylate
CAS No.:256488-00-3
Molecular Formula:C₁₇H₂₆N₂O₆S
Molecular Weight:386.469
Hs Code.:

Synonyms:methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(N-methoxyamino)pyrrolidine-(2R)-carboxylate

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Chemical Property of methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(N-methoxyamino)pyrrolidine-(2R)-carboxylate

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Technology Process of methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(N-methoxyamino)pyrrolidine-(2R)-carboxylate

There total 6 articles about methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(N-methoxyamino)pyrrolidine-(2R)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 247058-65-7
methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(Z,E-N-methoxyimino)pyrrolidine-(2R)-carboxylate

: 256488-00-3
methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(N-methoxyamino)pyrrolidine-(2R)-carboxylate

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In methanol; at 20 ℃;
DOI:10.1021/jm9904699

Reference yield:

: 1138-56-3
4-butoxybenzene-sulfonyl chloride

: 256488-00-3
methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(N-methoxyamino)pyrrolidine-(2R)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 37.4 g / Et₃N; 4-(dimethylamino)pyridine / dioxane; H₂O / 14 h / 20 °C

2: SOCl₂ / 14 h

3: Jones reagent / acetone / 14 h / 20 °C

4: 88 percent / sodium acetate / dioxane; methanol; H₂O / 20 °C

5: 71 percent / sodium cyanoborohydride; conc. aq. HCl / methanol / 20 °C

With hydrogenchloride; dmap; thionyl chloride; jones reagent; sodium acetate; sodium cyanoborohydride; triethylamine; In 1,4-dioxane; methanol; water; acetone; 1: sulfonylation / 2: Esterification / 3: Oxidation / 4: Condensation / 5: Reduction;
DOI:10.1021/jm9904699

Reference yield:

: 2584-71-6,30724-02-8
cis-hydroxy-D-proline

: 256488-00-3
methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(N-methoxyamino)pyrrolidine-(2R)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 37.4 g / Et₃N; 4-(dimethylamino)pyridine / dioxane; H₂O / 14 h / 20 °C

2: SOCl₂ / 14 h

3: Jones reagent / acetone / 14 h / 20 °C

4: 88 percent / sodium acetate / dioxane; methanol; H₂O / 20 °C

5: 71 percent / sodium cyanoborohydride; conc. aq. HCl / methanol / 20 °C

With hydrogenchloride; dmap; thionyl chloride; jones reagent; sodium acetate; sodium cyanoborohydride; triethylamine; In 1,4-dioxane; methanol; water; acetone; 1: sulfonylation / 2: Esterification / 3: Oxidation / 4: Condensation / 5: Reduction;
DOI:10.1021/jm9904699