methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(Z,E-N-methoxyimino)pyrrolidine-(2R)-carboxylate

Base Information

Chemical Name:methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(Z,E-N-methoxyimino)pyrrolidine-(2R)-carboxylate
CAS No.:247058-65-7
Molecular Formula:C₁₇H₂₄N₂O₆S
Molecular Weight:384.453
Hs Code.:

Synonyms:methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(Z,E-N-methoxyimino)pyrrolidine-(2R)-carboxylate

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Chemical Property of methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(Z,E-N-methoxyimino)pyrrolidine-(2R)-carboxylate

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Technology Process of methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(Z,E-N-methoxyimino)pyrrolidine-(2R)-carboxylate

There total 5 articles about methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(Z,E-N-methoxyimino)pyrrolidine-(2R)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 593-56-6
N-methoxylamine hydrochloride

: 203934-64-9
methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-oxo-pyrrolidine-(2R)-carboxylate

: 247058-65-7
methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(Z,E-N-methoxyimino)pyrrolidine-(2R)-carboxylate

Guidance literature:: With sodium acetate; In 1,4-dioxane; methanol; water; at 20 ℃;
DOI:10.1021/jm9904699

Reference yield:

: 1138-56-3
4-butoxybenzene-sulfonyl chloride

: 247058-65-7
methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(Z,E-N-methoxyimino)pyrrolidine-(2R)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 37.4 g / Et₃N; 4-(dimethylamino)pyridine / dioxane; H₂O / 14 h / 20 °C

2: SOCl₂ / 14 h

3: Jones reagent / acetone / 14 h / 20 °C

4: 88 percent / sodium acetate / dioxane; methanol; H₂O / 20 °C

With dmap; thionyl chloride; jones reagent; sodium acetate; triethylamine; In 1,4-dioxane; methanol; water; acetone; 1: sulfonylation / 2: Esterification / 3: Oxidation / 4: Condensation;
DOI:10.1021/jm9904699

Reference yield:

: 2584-71-6,30724-02-8
cis-hydroxy-D-proline

: 247058-65-7
methyl 1N-(4-n-butoxyphenyl)sulfonyl-4-(Z,E-N-methoxyimino)pyrrolidine-(2R)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 37.4 g / Et₃N; 4-(dimethylamino)pyridine / dioxane; H₂O / 14 h / 20 °C

2: SOCl₂ / 14 h

3: Jones reagent / acetone / 14 h / 20 °C

4: 88 percent / sodium acetate / dioxane; methanol; H₂O / 20 °C

With dmap; thionyl chloride; jones reagent; sodium acetate; triethylamine; In 1,4-dioxane; methanol; water; acetone; 1: sulfonylation / 2: Esterification / 3: Oxidation / 4: Condensation;
DOI:10.1021/jm9904699