2-(5-bromo-2-methoxyphenyl)-8-chloro-4-(3,4-dimethoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepine

Base Information

Chemical Name:2-(5-bromo-2-methoxyphenyl)-8-chloro-4-(3,4-dimethoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepine
CAS No.:1401506-18-0
Molecular Formula:C₂₄H₂₁BrClNO₃S
Molecular Weight:518.859
Hs Code.:

Synonyms:2-(5-bromo-2-methoxyphenyl)-8-chloro-4-(3,4-dimethoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepine

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Chemical Property of 2-(5-bromo-2-methoxyphenyl)-8-chloro-4-(3,4-dimethoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepine

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Technology Process of 2-(5-bromo-2-methoxyphenyl)-8-chloro-4-(3,4-dimethoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepine

There total 5 articles about 2-(5-bromo-2-methoxyphenyl)-8-chloro-4-(3,4-dimethoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 23474-98-8
2-amino-5-chlorobenzenethiol

: 352011-42-8
3-(5-bromo-2-methoxyphenyl)-1-(3,4-dimethoxyphenyl)propen-1-one

: 1401506-18-0
2-(5-bromo-2-methoxyphenyl)-8-chloro-4-(3,4-dimethoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepine

Guidance literature:: 2-amino-5-chlorobenzenethiol; 3-(5-bromo-2-methoxyphenyl)-1-(3,4-dimethoxyphenyl)propen-1-one; In ethanol; Reflux;

With acetic acid; In ethanol; for 3h; Reflux;
DOI:10.1007/s11164-012-0782-8

Reference yield:

: 25016-01-7
5-bromo-2-methoxybenzaldehyde

: 1401506-18-0
2-(5-bromo-2-methoxyphenyl)-8-chloro-4-(3,4-dimethoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 0.08 h / 20 °C

1.2: 0.25 h / 20 °C

2.1: ethanol / Reflux

2.2: 3 h / Reflux

With sodium hydroxide; In ethanol; 1.1: |Claisen-Schmidt Condensation / 1.2: |Claisen-Schmidt Condensation;
DOI:10.1007/s11164-012-0782-8

Reference yield:

: 3696-23-9
N-(4-chlorophenyl)thiourea

: 1401506-18-0
2-(5-bromo-2-methoxyphenyl)-8-chloro-4-(3,4-dimethoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepine

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine / chloroform / 4 h / 5 °C

2.1: potassium hydroxide / water / Reflux

3.1: ethanol / Reflux

3.2: 3 h / Reflux

With bromine; potassium hydroxide; In ethanol; chloroform; water;
DOI:10.1007/s11164-012-0782-8