Technology Process of C21H30FNO3
There total 10 articles about C21H30FNO3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(2-fluoroethyloxybenzyl)-4-(cis-3a,4,5,6,7,7a-hexahydroisoindolin-2-yl)-4-oxobutanoic acid;
With
triethylamine; isobutyl chloroformate;
In
tetrahydrofuran;
at -10 ℃;
for 3h;
With
sodium tetrahydroborate;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 1h;
DOI:10.1016/j.bmc.2014.04.059
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: acetic anhydride / dichloromethane / 1.5 h / 60 °C
2.1: dichloromethane / 5 h / 0 - 20 °C
3.1: thionyl chloride / 15.5 h / 0 - 20 °C
4.1: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr
5.1: caesium carbonate / N,N-dimethyl-formamide / 17.5 h / 60 °C
6.1: sodium hydroxide; water / 1,4-dioxane / 50 °C
7.1: trifluoroacetic acid / methanol; acetonitrile / Resolution of racemate
8.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / 3 h / -10 °C
8.2: 1 h / 0 - 20 °C
With
thionyl chloride; palladium 10% on activated carbon; water; hydrogen; acetic anhydride; caesium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; isobutyl chloroformate;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2014.04.059
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: potassium hydroxide / dimethyl sulfoxide / 15 h / 80 °C
2.1: sodium hydroxide; water / dimethyl sulfoxide / 5 h / 120 °C
3.1: acetic anhydride / dichloromethane / 1.5 h / 60 °C
4.1: dichloromethane / 5 h / 0 - 20 °C
5.1: thionyl chloride / 15.5 h / 0 - 20 °C
6.1: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr
7.1: caesium carbonate / N,N-dimethyl-formamide / 17.5 h / 60 °C
8.1: sodium hydroxide; water / 1,4-dioxane / 50 °C
9.1: trifluoroacetic acid / methanol; acetonitrile / Resolution of racemate
10.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / 3 h / -10 °C
10.2: 1 h / 0 - 20 °C
With
thionyl chloride; palladium 10% on activated carbon; water; hydrogen; acetic anhydride; caesium carbonate; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; isobutyl chloroformate;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2014.04.059
