methyl 2-(2-benzyloxybenzylidene)-4-oxo-4-(cis-3a,4,7,7a-tetrahydroisoindolin-2-yl)butanoate

Base Information

Chemical Name:methyl 2-(2-benzyloxybenzylidene)-4-oxo-4-(cis-3a,4,7,7a-tetrahydroisoindolin-2-yl)butanoate
CAS No.:1613033-21-8
Molecular Formula:C₂₇H₂₉NO₄
Molecular Weight:431.532
Hs Code.:

Synonyms:methyl 2-(2-benzyloxybenzylidene)-4-oxo-4-(cis-3a,4,7,7a-tetrahydroisoindolin-2-yl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-(2-benzyloxybenzylidene)-4-oxo-4-(cis-3a,4,7,7a-tetrahydroisoindolin-2-yl)butanoate

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Technology Process of methyl 2-(2-benzyloxybenzylidene)-4-oxo-4-(cis-3a,4,7,7a-tetrahydroisoindolin-2-yl)butanoate

There total 5 articles about methyl 2-(2-benzyloxybenzylidene)-4-oxo-4-(cis-3a,4,7,7a-tetrahydroisoindolin-2-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: C₂₆H₂₇NO₄

: 1613033-21-8
methyl 2-(2-benzyloxybenzylidene)-4-oxo-4-(cis-3a,4,7,7a-tetrahydroisoindolin-2-yl)butanoate

Guidance literature:: With thionyl chloride; at 0 - 20 ℃; for 15.5h;
DOI:10.1016/j.bmc.2014.04.059

Reference yield:

: 1613033-20-7
2-(2-benzyloxybenzylidene)succinic acid

: 1613033-21-8
methyl 2-(2-benzyloxybenzylidene)-4-oxo-4-(cis-3a,4,7,7a-tetrahydroisoindolin-2-yl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic anhydride / dichloromethane / 1.5 h / 60 °C

2: dichloromethane / 5 h / 0 - 20 °C

3: thionyl chloride / 15.5 h / 0 - 20 °C

With thionyl chloride; acetic anhydride; In dichloromethane;
DOI:10.1016/j.bmc.2014.04.059

Reference yield:

: 5896-17-3
2-(phenylmethoxy)benzaldehyde

: 1613033-21-8
methyl 2-(2-benzyloxybenzylidene)-4-oxo-4-(cis-3a,4,7,7a-tetrahydroisoindolin-2-yl)butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / dimethyl sulfoxide / 15 h / 80 °C

2: sodium hydroxide; water / dimethyl sulfoxide / 5 h / 120 °C

3: acetic anhydride / dichloromethane / 1.5 h / 60 °C

4: dichloromethane / 5 h / 0 - 20 °C

5: thionyl chloride / 15.5 h / 0 - 20 °C

With thionyl chloride; water; acetic anhydride; potassium hydroxide; sodium hydroxide; In dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2014.04.059