tert-butyl-2-[2-(4-oxo-4H-benzo[d][1,2,3]-triazin-3-ylethyl)]-3-(4-bromo-phenylthio)propionate

Base Information

Chemical Name:tert-butyl-2-[2-(4-oxo-4H-benzo[d][1,2,3]-triazin-3-ylethyl)]-3-(4-bromo-phenylthio)propionate
CAS No.:427895-03-2
Molecular Formula:C₂₂H₂₄BrN₃O₃S
Molecular Weight:490.421
Hs Code.:

Synonyms:tert-butyl-2-[2-(4-oxo-4H-benzo[d][1,2,3]-triazin-3-ylethyl)]-3-(4-bromo-phenylthio)propionate

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Chemical Property of tert-butyl-2-[2-(4-oxo-4H-benzo[d][1,2,3]-triazin-3-ylethyl)]-3-(4-bromo-phenylthio)propionate

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Technology Process of tert-butyl-2-[2-(4-oxo-4H-benzo[d][1,2,3]-triazin-3-ylethyl)]-3-(4-bromo-phenylthio)propionate

There total 8 articles about tert-butyl-2-[2-(4-oxo-4H-benzo[d][1,2,3]-triazin-3-ylethyl)]-3-(4-bromo-phenylthio)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 90-16-4
1,2,3-benzotriazin-4(3H)-one

: 427895-02-1
tert-butyl-2-(2-hydroxy-ethyl)-3-(4-bromophenylthio) propionate

: 427895-03-2
tert-butyl-2-[2-(4-oxo-4H-benzo[d][1,2,3]-triazin-3-ylethyl)]-3-(4-bromo-phenylthio)propionate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;
DOI:10.1016/S0968-0896(01)00311-X

Reference yield:

: 97-65-4,25119-64-6
2-methylenesuccinic acid

: 427895-03-2
tert-butyl-2-[2-(4-oxo-4H-benzo[d][1,2,3]-triazin-3-ylethyl)]-3-(4-bromo-phenylthio)propionate

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / Amberlyst 15 H⁺ resin / 72 h / 20 °C

2: 67.5 percent / H₂SO₄ / CH₂Cl₂ / 0 - 20 °C

3: 75.3 percent / LiOH / H₂O; dioxane / 2.5 h / 0 - 20 °C

4: 80.2 percent / NaOMe / methanol / 20 °C

5: N-methylmorpholine / 1,2-dimethoxy-ethane / 20 °C

6: 34 g / NaBH₄ / 1,2-dimethoxy-ethane; H₂O / 1 h / -10 °C

7: 88 percent / Ph₃P; DIAD / tetrahydrofuran / 1.5 h / 0 - 20 °C

With 4-methyl-morpholine; lithium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; Amberlyst 15 H⁺ resin; sulfuric acid; sodium methylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; 7: Mitsunobu reaction;
DOI:10.1016/S0968-0896(01)00311-X

Reference yield:

: 7338-27-4
4-methoxy-2-methylene-4-oxobutanoic acid

: 427895-03-2
tert-butyl-2-[2-(4-oxo-4H-benzo[d][1,2,3]-triazin-3-ylethyl)]-3-(4-bromo-phenylthio)propionate

Guidance literature:: Multi-step reaction with 6 steps

1: 67.5 percent / H₂SO₄ / CH₂Cl₂ / 0 - 20 °C

2: 75.3 percent / LiOH / H₂O; dioxane / 2.5 h / 0 - 20 °C

3: 80.2 percent / NaOMe / methanol / 20 °C

4: N-methylmorpholine / 1,2-dimethoxy-ethane / 20 °C

5: 34 g / NaBH₄ / 1,2-dimethoxy-ethane; H₂O / 1 h / -10 °C

6: 88 percent / Ph₃P; DIAD / tetrahydrofuran / 1.5 h / 0 - 20 °C

With 4-methyl-morpholine; lithium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; sulfuric acid; sodium methylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; 6: Mitsunobu reaction;
DOI:10.1016/S0968-0896(01)00311-X