3-(4-HYDROXYBENZYL)-2,4-PENTANEDIONE

Base Information

• Chemical Name: 3-(4-HYDROXYBENZYL)-2,4-PENTANEDIONE
• CAS No.: 15451-07-7
• Molecular Formula: C12H14O3
• Molecular Weight: 206.241
• Hs Code.: 2914500090
• Mol file: 15451-07-7.mol

Synonyms:3-(4-hydroxy-benzyl)-pentane-2,4-dione;3-(4'-Hydroxybenzyl)-2,4-pentandion [German];3-<4-Hydroxy-benzyl>-pentan-2,4-dion;2,4-Pentanedione,3-(p-hydroxybenzyl);3-<(4-Hydroxyphenyl)methyl>pentane-2,4-dione;3-(p-Hydroxybenzyl)-2,4-pentanedione;3-(4-Hydroxybenzyl)-1,3-pentandion;2,4-Pentanedione,3-((4-hydroxyphenyl)methyl);3(4'-HYDROXYBENZYL)-2,4-PENTANEDIONE;3-(4'-Hydroxybenzyl)-2,4-pentandion;

Chemical Property of 3-(4-HYDROXYBENZYL)-2,4-PENTANEDIONE

Chemical Property:

• Vapor Pressure: 2.64E-05mmHg at 25°C
• Melting Point: 69 °C
• Boiling Point: 347.7°Cat760mmHg
• PKA: 9.82±0.15(Predicted)
• Flash Point: 178.3°C
• PSA: 54.37000
• Density: 1.137g/cm³
• LogP: 1.72890

Purity/Quality:

99% ^*data from raw suppliers

3-(4-HYDROXYBENZYL)-2,4-PENTANEDIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-HYDROXYBENZYL)-2,4-PENTANEDIONE

There total 10 articles about 3-(4-HYDROXYBENZYL)-2,4-PENTANEDIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-acetyl-3-(4-hydroxyphenyl)-1-methylpropenone (17792-58-4) → 3-<(4-Hydroxyphenyl)methyl>pentane-2,4-dione (15451-07-7)

Guidance literature:

With hydrogen; nickel; In ethanol; for 36h; Ambient temperature;

Reference yield: 93.0%

3-<<4-(Benzyloxy)phenyl>methyl>pentane-2,4-dione (160979-66-8) → 3-<(4-Hydroxyphenyl)methyl>pentane-2,4-dione (15451-07-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In dichloromethane; for 8h; Ambient temperature;

DOI:10.1021/jo00115a023

Reference yield: 78.0%

4-hydroxybenzyl chloride (35421-08-0) → 3-<(4-Hydroxyphenyl)methyl>pentane-2,4-dione (15451-07-7)

Guidance literature:

In acetonitrile;

upstream raw materials:

2-acetyl-3-(4-hydroxyphenyl)-1-methylpropenone

(4-hydroxyphenyl)methanol

acetylacetone

3-<<4-(Benzyloxy)phenyl>methyl>pentane-2,4-dione

Downstream raw materials:

3-<<4-(n-Decyloxy)phenyl>methyl>pentane-2,4-dione

Thiophosphorsaeure-O-<4-<1-(diethoxythiophosphoryl)-3,5-dimethylpyrazol-4-ylmethyl>-phenyl>-O,O-diethylester

Chloressigsaeure-<4-<1-(3-chlorphenyl)-3,5-dimethylpyrazol-4-ylmethyl>phenylester>

Methylcarbaminsaeure-<4-<1-(3-chlorphenyl)-3,5-dimethylpyrazol-4-ylmethyl>phenylester>

Refernces

• 1、 Cativiela, Carlos,Serrano, Jose L.,Zurbano, Maria M.. "Synthesis of 3-Substituted Pentane-2,4-diones: Valuable Intermediates for Liquid Crystals". . p. 3074 - 3083. Retrieved 2007/10/02.
• 2、 Kuebel, Boerries. "Simple Synthesis of 4-(Heteroarylmethyl)phenols and Their Acylation". . p. 1392 - 1401. Retrieved 2007/10/02.