2-amino-6-(2-(5-methyl-3-phenylisoxazol-4-yl)-2-oxoethyl)-4-(furan-2-yl)pyridine-3,5-dicarbonitrile

Base Information

• Chemical Name: 2-amino-6-(2-(5-methyl-3-phenylisoxazol-4-yl)-2-oxoethyl)-4-(furan-2-yl)pyridine-3,5-dicarbonitrile
• CAS No.: 918901-53-8
• Molecular Formula: C₂₃H₁₅N₅O₃S
• Molecular Weight: 441.47
• Mol file: 918901-53-8.mol

Synonyms:2-amino-6-(2-(5-methyl-3-phenylisoxazol-4-yl)-2-oxoethyl)-4-(furan-2-yl)pyridine-3,5-dicarbonitrile

Chemical Property of 2-amino-6-(2-(5-methyl-3-phenylisoxazol-4-yl)-2-oxoethyl)-4-(furan-2-yl)pyridine-3,5-dicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-6-(2-(5-methyl-3-phenylisoxazol-4-yl)-2-oxoethyl)-4-(furan-2-yl)pyridine-3,5-dicarbonitrile

There total 3 articles about 2-amino-6-(2-(5-methyl-3-phenylisoxazol-4-yl)-2-oxoethyl)-4-(furan-2-yl)pyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-amino-4-(2-furyl)-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile (123518-00-3) → 2-amino-6-(2-(5-methyl-3-phenylisoxazol-4-yl)-2-oxoethyl)-4-(furan-2-yl)pyridine-3,5-dicarbonitrile (918901-53-8)

Guidance literature:

6-amino-4-(2-furyl)-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile; With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 0.0166667h;

2-(5-methyl-3-phenylisoxazol-4-yl)-2-oxoethyl halide; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1021/jm061045z

Reference yield:

furfural (98-01-1) → 2-amino-6-(2-(5-methyl-3-phenylisoxazol-4-yl)-2-oxoethyl)-4-(furan-2-yl)pyridine-3,5-dicarbonitrile (918901-53-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: β-alanine / ethanol / 72 h / 20 °C

2.1: piperidine / ethanol / 5 h / 80 °C

3.1: aq. KOH / dimethylformamide / 0.02 h / 20 °C

3.2: dimethylformamide / 5 h / 20 °C

With piperidine; potassium hydroxide; 3-amino propanoic acid; In ethanol; N,N-dimethyl-formamide; 1.1: Knoevenagel condensation;

DOI:10.1021/jm061045z

Reference yield:

2-cyano-3-(2-furanyl)acrylonitrile (3237-22-7) → 2-amino-6-(2-(5-methyl-3-phenylisoxazol-4-yl)-2-oxoethyl)-4-(furan-2-yl)pyridine-3,5-dicarbonitrile (918901-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: piperidine / ethanol / 5 h / 80 °C

2.1: aq. KOH / dimethylformamide / 0.02 h / 20 °C

2.2: dimethylformamide / 5 h / 20 °C

With piperidine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm061045z

upstream raw materials:

6-amino-4-(2-furyl)-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile

furfural

2-cyano-3-(2-furanyl)acrylonitrile