N-(2-hydroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

Base Information

Chemical Name:N-(2-hydroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide
CAS No.:1541832-11-4
Molecular Formula:C₂₂H₂₄FN₃O₄S
Molecular Weight:445.515
Hs Code.:

Synonyms:N-(2-hydroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

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Chemical Property of N-(2-hydroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

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Technology Process of N-(2-hydroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

There total 6 articles about N-(2-hydroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1541832-52-3
N-(2-nitrooxyethyl)-2-(benzyloxy)carbonylamino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

: 1541832-11-4
N-(2-hydroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

Guidance literature:: With palladium on activated charcoal; ammonium formate; In isopropyl alcohol; at 80 ℃; for 0.0833333h; under 8791.75 Torr; Microwave irradiation;
DOI:10.1016/j.bmc.2013.12.008

Reference yield:

: ethyl 2-[1-(3-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]-2-(hydroxylamino)ylidene-acetate

: 1541832-11-4
N-(2-hydroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: formic acid; zinc / ethanol / 20 h / 0 - 20 °C

2: sodium carbonate / dichloromethane; water / 4 h / 0 - 20 °C

3: sodium hydroxide; hydrogenchloride / water; methanol / 17 h / 20 °C

4: triethylamine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere

5: palladium on activated charcoal; ammonium formate / isopropyl alcohol / 0.08 h / 80 °C / 8791.75 Torr / Microwave irradiation

With hydrogenchloride; dmap; formic acid; palladium on activated charcoal; ammonium formate; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; zinc; In methanol; ethanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1016/j.bmc.2013.12.008

Reference yield:

: 1363375-46-5
ethyl N-(benzyloxycarbonyl)-2-amino-2-[1-(3-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]-acetate

: 1541832-11-4
N-(2-hydroxyethyl)-2-amino-2-(1-(3-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; hydrogenchloride / water; methanol / 17 h / 20 °C

2: triethylamine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere

3: palladium on activated charcoal; ammonium formate / isopropyl alcohol / 0.08 h / 80 °C / 8791.75 Torr / Microwave irradiation

With hydrogenchloride; dmap; palladium on activated charcoal; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1016/j.bmc.2013.12.008